Frizzled Homolog 8 (FZD8) Antibody
52€ (10 µg)
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Name
Frizzled Homolog 8 (FZD8) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx015285
Tested Applications
ELISA, WB
Description
Rabbit polyclonal antibody against FZD8 protein. Immunogen region is C-terminal.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Frizzled Homolog 8 (FZD8) Immunogen: The antiserum was produced against synthesized peptide derived from C-terminal of human FZD8. |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | WB: 1/500 - 1/3000, ELISA: 1/5000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9H461 |
| Alias | FZD8,FZ-8,hFZ8,frizzled family receptor 8,Fz8 |
| Background | Antibody anti-FZD8 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
FZD8 is a member of the Frizzled receptor family that mediates Wnt signaling, predominantly through the canonical β-catenin-dependent pathway. It is expressed in various tissues, including the brain, heart, and bone, where it regulates cell proliferation, differentiation, and tissue homeostasis. FZD8 plays a significant role in bone formation and osteoblast differentiation, making it essential for skeletal development and regeneration. In cancer, FZD8 is overexpressed in lung, breast, and prostate cancers, where it promotes cell proliferation, survival, and therapy resistance through enhanced Wnt/β-catenin signaling. FZD8 also contributes to angiogenesis and metastasis by regulating endothelial cell function and tumor vascularization. Its role in brain development includes regulating neural differentiation and synaptic plasticity. FZD8 activation triggers downstream pathways like PI3K/Akt and MAPK, driving cellular responses critical for growth and repair. Dysregulation of FZD8 is associated with developmental defects, cancer progression, and bone disorders. Therapeutic targeting of FZD8 to modulate Wnt signaling is being explored to treat cancers and bone-related diseases, highlighting its importance in development and disease.
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