Mouse Frizzled Homolog 1 (FZD1) Protein
221€ (10 µg)
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935106861
info@markelab.com
name
Mouse Frizzled Homolog 1 (FZD1) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx167220
tested applications
WB, SDS-PAGE
Description
Frizzled Homolog 1 Protein is a recombinant Mouse protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Frizzled Homolog 1 (FZD1) |
| Host | E. coli |
| Origin | Mouse |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 26.6 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Gln112-Trp317 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O70421 |
| Alias | FDZ1,Fz1,Wnt receptor,frizzled family receptor 1,Frizzled-1 |
| Background | Protein FZD1 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
FZD1 is a member of the Frizzled family of G protein-coupled receptors (GPCRs) that function as receptors for Wnt signaling proteins. It is widely expressed in various tissues, including the kidney, brain, and bone, and plays a pivotal role in the canonical Wnt/β-catenin pathway and non-canonical pathways like planar cell polarity (PCP) and calcium signaling. FZD1 regulates critical cellular processes such as proliferation, differentiation, and migration during embryogenesis, tissue repair, and homeostasis. In bone biology, FZD1 mediates osteoblast differentiation and mineralization, promoting bone formation. Dysregulation of FZD1 has been linked to cancer, where it contributes to cell proliferation, survival, and metastasis, particularly in breast, lung, and colorectal cancers. Its overexpression enhances Wnt/β-catenin signaling, driving tumor progression and therapy resistance. FZD1 also regulates stem cell maintenance and epithelial-mesenchymal transition (EMT), processes critical for tissue regeneration and cancer metastasis. Additionally, its role in cardiac and renal development highlights its importance in organogenesis. Targeting FZD1 and its associated pathways is being explored in cancer therapy and regenerative medicine to modulate Wnt signaling and control disease progression.
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