Human Frizzled Homolog 1 (FZD1) Protein
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935106861
info@markelab.com
Precio
195€ (10 µg)
Protein FZD1
proveedor
Abbexareference
abx066693Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Recombinant Frizzled Homolog 1 (FZD1) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Background
FZD1 is a member of the Frizzled family of G protein-coupled receptors (GPCRs) that function as receptors for Wnt signaling proteins. It is widely expressed in various tissues, including the kidney, brain, and bone, and plays a pivotal role in the canonical Wnt/β-catenin pathway and non-canonical pathways like planar cell polarity (PCP) and calcium signaling. FZD1 regulates critical cellular processes such as proliferation, differentiation, and migration during embryogenesis, tissue repair, and homeostasis. In bone biology, FZD1 mediates osteoblast differentiation and mineralization, promoting bone formation. Dysregulation of FZD1 has been linked to cancer, where it contributes to cell proliferation, survival, and metastasis, particularly in breast, lung, and colorectal cancers. Its overexpression enhances Wnt/β-catenin signaling, driving tumor progression and therapy resistance. FZD1 also regulates stem cell maintenance and epithelial-mesenchymal transition (EMT), processes critical for tissue regeneration and cancer metastasis. Additionally, its role in cardiac and renal development highlights its importance in organogenesis. Targeting FZD1 and its associated pathways is being explored in cancer therapy and regenerative medicine to modulate Wnt signaling and control disease progression.
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
Frizzled Homolog 1 (FZD1)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 26.5 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Gln117-Trp322 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
FZD1
dry ice
No
availability
Shipped within 5-7 working days.
alias
FDZ1,Fz1,Wnt receptor,frizzled family receptor 1,Frizzled-1
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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