Mouse Frizzled-7 (FZD7) ELISA Kit
715€ (96 tests)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Mouse Frizzled-7 (FZD7) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx524553
tested applications
ELISA
Description
Mouse Frizzled-7 (FZD7) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Frizzled-7 concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Frizzled-7 (FZD7) |
| Reactivity | Mouse |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q61090 |
| Gene ID | 14369 |
| Alias | FZD7,Frizzled Homolog 7,FzE3,frizzled family receptor 7,Fzd7,Fz7 |
| Background | Elisa kits for FZD7 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
FZD7 is a Wnt receptor involved in both canonical β-catenin-dependent signaling and non-canonical pathways, playing a critical role in cell proliferation, migration, and stem cell maintenance. It is highly expressed in embryonic tissues, intestinal epithelium, and cancer cells. FZD7 regulates intestinal stem cell renewal and differentiation, contributing to gut homeostasis and regeneration. In cancer, FZD7 is overexpressed in tumors such as gastric, colorectal, and hepatocellular carcinomas, where it drives Wnt/β-catenin signaling to promote cell proliferation, survival, and therapy resistance. FZD7 also plays a role in epithelial-mesenchymal transition (EMT) and metastasis, enabling cancer cells to invade and spread. Its involvement in stem cell biology highlights its importance in tissue repair and cancer stem cell maintenance. Additionally, FZD7 regulates non-canonical signaling pathways like planar cell polarity (PCP), controlling cell migration and polarity during development. Targeting FZD7 has been proposed as a therapeutic strategy to inhibit Wnt signaling in cancer and regenerative medicine, as its dysregulation contributes to tumorigenesis and disease progression.
Related Products
FZD7 antibody
Ver Producto
Recombinant Human FZD7
Ver Producto
Frizzled Homolog 7 (FZD7) Antibody
FZD7 Antibody is a Rabbit Polyclonal antibody against FZD7. Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.
Ver Producto