Frizzled Homolog 7 (FZD7) Antibody
312€ (100 µg)
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935106861
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name
Frizzled Homolog 7 (FZD7) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx018135
tested applications
ELISA, WB
Description
FzE3 Antibody is a Mouse Monoclonal antibody against FzE3.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Frizzled Homolog 7 (FZD7) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG2a |
| Purification | Purified from ascites by Protein A chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | Citrate-Tris-HCl, pH 7.0, with 0.02% Proclin-300. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O75084 |
| Alias | FZD7,Frizzled Homolog 7,FzE3,frizzled family receptor 7,Fzd7,Fz7 |
| Background | Antibody anti-FZD7 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
FZD7 is a Wnt receptor involved in both canonical β-catenin-dependent signaling and non-canonical pathways, playing a critical role in cell proliferation, migration, and stem cell maintenance. It is highly expressed in embryonic tissues, intestinal epithelium, and cancer cells. FZD7 regulates intestinal stem cell renewal and differentiation, contributing to gut homeostasis and regeneration. In cancer, FZD7 is overexpressed in tumors such as gastric, colorectal, and hepatocellular carcinomas, where it drives Wnt/β-catenin signaling to promote cell proliferation, survival, and therapy resistance. FZD7 also plays a role in epithelial-mesenchymal transition (EMT) and metastasis, enabling cancer cells to invade and spread. Its involvement in stem cell biology highlights its importance in tissue repair and cancer stem cell maintenance. Additionally, FZD7 regulates non-canonical signaling pathways like planar cell polarity (PCP), controlling cell migration and polarity during development. Targeting FZD7 has been proposed as a therapeutic strategy to inhibit Wnt signaling in cancer and regenerative medicine, as its dysregulation contributes to tumorigenesis and disease progression.
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