Mouse Frizzled-5 (FZD5) ELISA Kit

Este producto es parte de FZD - Frizzled Homolog
Mouse Frizzled-5 (FZD5) ELISA Kit
715€ (96 tests)

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Name
Mouse Frizzled-5 (FZD5) ELISA Kit
Category
ELISA Kits
Provider
Abbexa
Reference
abx524545
Tested Applications
ELISA

Description

Mouse Frizzled-5 (FZD5) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Frizzled-5 concentrations in tissue homogenates, cell lysates and other biological fluids.

Documentos del producto

Instrucciones
Data sheet
Descargar

Especificaciones del producto

Category
ELISA Kits
Immunogen Target
Frizzled-5 (FZD5)
Reactivity
Mouse
Detection Method
Colorimetric
Assay Data
Quantitative
Test Range
0.156 ng/ml - 10 ng/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Form
Standard Form: Lyophilized
Tested Applications
ELISA
Sample Type
Tissue homogenates, cell lysates and other biological fluids.
Availability
Shipped within 5-15 working days.
Storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
UniProt ID
Q9EQD0
Gene ID
14367
Alias
FZD5,HFZ5,C2orf31,frizzled family receptor 5,Fz5
Background
Elisa Kits for: FZD5
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout.

Background

FZD5 is a member of the Frizzled family of G protein-coupled receptors that primarily mediates canonical Wnt/β-catenin signaling and non-canonical Wnt pathways. It is widely expressed in tissues such as the gut, pancreas, brain, and placenta, playing critical roles in embryonic development, cell proliferation, and differentiation. FZD5 is essential for intestinal development and homeostasis, where it regulates Wnt-dependent stem cell maintenance and epithelial regeneration. In the central nervous system, FZD5 contributes to neural development and synaptic function. Its dysregulation is implicated in developmental disorders and diseases such as cancer. FZD5 overexpression in cancers like pancreatic and colorectal tumors enhances cell proliferation, survival, and resistance to therapies through Wnt/β-catenin activation. Additionally, FZD5 regulates angiogenesis by interacting with Wnt ligands, promoting vascular endothelial cell proliferation and survival. In placental biology, FZD5 is critical for trophoblast differentiation and vascular remodeling. Targeting FZD5 has emerged as a potential therapeutic strategy for cancer, inflammatory bowel disease, and other Wnt-driven pathologies due to its pivotal role in tissue homeostasis and disease progression.

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