Frizzled Homolog 5 (FZD5) Antibody
338€ (100 µg)
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Name
Frizzled Homolog 5 (FZD5) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx019087
Tested Applications
WB, IF/ICC
Description
Frizzled 5 Antibody is a Rabbit Polyclonal antibody against Human.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Frizzled Homolog 5 (FZD5) Immunogen: A synthetic peptide (conjugated with KLH) corresponding to the region of human Frizzled 5. |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Immunogen affinity purified. |
| Size 1 | 100 µg |
| Tested Applications | WB, IF/ICC |
| Buffer | TBS, pH 7.4, 0.5% BSA, 40% glycerol and 0.05% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q13467 |
| Gene ID | 7855 |
| OMIM | 601723 |
| Alias | FZD5,HFZ5,C2orf31,frizzled family receptor 5,Fz5 |
| Background | Antibody anti-FZD5 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
FZD5 is a member of the Frizzled family of G protein-coupled receptors that primarily mediates canonical Wnt/β-catenin signaling and non-canonical Wnt pathways. It is widely expressed in tissues such as the gut, pancreas, brain, and placenta, playing critical roles in embryonic development, cell proliferation, and differentiation. FZD5 is essential for intestinal development and homeostasis, where it regulates Wnt-dependent stem cell maintenance and epithelial regeneration. In the central nervous system, FZD5 contributes to neural development and synaptic function. Its dysregulation is implicated in developmental disorders and diseases such as cancer. FZD5 overexpression in cancers like pancreatic and colorectal tumors enhances cell proliferation, survival, and resistance to therapies through Wnt/β-catenin activation. Additionally, FZD5 regulates angiogenesis by interacting with Wnt ligands, promoting vascular endothelial cell proliferation and survival. In placental biology, FZD5 is critical for trophoblast differentiation and vascular remodeling. Targeting FZD5 has emerged as a potential therapeutic strategy for cancer, inflammatory bowel disease, and other Wnt-driven pathologies due to its pivotal role in tissue homeostasis and disease progression.
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