Mouse Frizzled 2 (FZD2) Protein
247€ (10 µg)
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935106861
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name
Mouse Frizzled 2 (FZD2) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx691355
tested applications
SDS-PAGE
Description
Mouse Frizzled 2 Protein is a recombinant protein from Mouse produced in Human Cells. Recombinant Mouse frizzled (Drosophila) homolog 2 is produced by our Mammalian expression system and the target gene encoding Gln29-Leu168 is expressed with a Fc tag at the C-terminus.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Frizzled 2 (FZD2) |
| Host | Human |
| Origin | Mouse |
| Observed MW | Molecular Weight: 42.9 kDa Sequence Fragment: Gln29-Leu168 Tag: C-terminal Fc tag |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Form | Lyophilized |
| Tested Applications | SDS-PAGE |
| Buffer | PBS, pH7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Store at < -20°C. |
| Dry Ice | No |
| UniProt ID | Q9JIP6 |
| Alias | FDZ2,Fz2,Frizzled-2,frizzled family receptor 2,Fzd10,Fz10,fz-2,fzE2,hFz2,OMOD2 |
| Background | Protein FZD2 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
FZD2 is a G protein-coupled receptor that binds Wnt ligands, mediating both canonical (β-catenin-dependent) and non-canonical (PCP and calcium) Wnt signaling pathways. It is expressed in various tissues, including the heart, lung, and skeletal system, where it regulates embryonic development, tissue remodeling, and cellular signaling. FZD2 plays a critical role in cell migration and polarity during embryogenesis, particularly in neural tube closure, heart development, and limb patterning. In cancer, FZD2 is upregulated in tumors such as gastric, liver, and lung cancers, where it enhances epithelial-mesenchymal transition (EMT), cell invasion, and metastasis through Wnt/β-catenin-independent pathways. FZD2 has also been implicated in fibrosis, including pulmonary and hepatic fibrosis, where its activation drives myofibroblast differentiation and excessive extracellular matrix production. Dysregulation of FZD2 signaling contributes to developmental abnormalities and chronic diseases. Pharmacological targeting of FZD2 offers therapeutic potential in cancer and fibrotic diseases by inhibiting aberrant Wnt signaling and EMT processes. Its role in cellular polarity and migration underscores its importance in both normal development and disease progression.
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