Frizzled Homolog 2 (FZD2) Antibody
52€ (10 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Frizzled Homolog 2 (FZD2) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx015246
Tested Applications
ELISA, WB, IF/ICC
Description
Rabbit polyclonal antibody against FZD2 protein. Immunogen region is Internal.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Frizzled Homolog 2 (FZD2) Immunogen: The antiserum was produced against synthesized peptide derived from internal of human FZD2. |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | WB: 1/500 - 1/3000, IF/ICC: 1/100 - 1/500, ELISA: 1/40000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IF/ICC |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q14332 |
| Alias | FDZ2,Fz2,Frizzled-2,frizzled family receptor 2,Fzd10,Fz10,fz-2,fzE2,hFz2,OMOD2 |
| Background | Antibody anti-FZD2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
FZD2 is a G protein-coupled receptor that binds Wnt ligands, mediating both canonical (β-catenin-dependent) and non-canonical (PCP and calcium) Wnt signaling pathways. It is expressed in various tissues, including the heart, lung, and skeletal system, where it regulates embryonic development, tissue remodeling, and cellular signaling. FZD2 plays a critical role in cell migration and polarity during embryogenesis, particularly in neural tube closure, heart development, and limb patterning. In cancer, FZD2 is upregulated in tumors such as gastric, liver, and lung cancers, where it enhances epithelial-mesenchymal transition (EMT), cell invasion, and metastasis through Wnt/β-catenin-independent pathways. FZD2 has also been implicated in fibrosis, including pulmonary and hepatic fibrosis, where its activation drives myofibroblast differentiation and excessive extracellular matrix production. Dysregulation of FZD2 signaling contributes to developmental abnormalities and chronic diseases. Pharmacological targeting of FZD2 offers therapeutic potential in cancer and fibrotic diseases by inhibiting aberrant Wnt signaling and EMT processes. Its role in cellular polarity and migration underscores its importance in both normal development and disease progression.
Productos relacionados
Frizzled Homolog 2 (FZD2) Antibody
Rabbit polyclonal antibody against FZD2 protein. Immunogen region is Internal.…
Ver producto