Mouse FPR2(Formyl Peptide Receptor 2) ELISA Kit

Este producto es parte de FPR - Formyl Peptide Receptor
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935106861
info@markelab.com
name
Mouse FPR2(Formyl Peptide Receptor 2) ELISA Kit
category
ELISA Kits
provider
FineTest
reference
EM1033

Documents del producto

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Data sheet

Product specifications

CategoryELISA Kits
Reactivitymouse
Detection MethodColorimetric
Assay DataQuantitative
Assay TypeSandwich ELISA, Double Antibody
Test Range31.25-2000pg/ml
Size 196T
Sample TypeSerum,Plasma,Tissue homogenates,Other biological fluids
AvailabilityShipped within 10-14 working days.
Storage2-8 °C for 6 months
UniProt IDO88536
AliasFPR2,ALXR,FMLPX,FPRH1,LXA4R,ALX,FPRH2,FPRL1,RFP,formyl peptide receptor-like 1,HM63,FMLP-R-II
BackgroundElisa Kits FPR2
StatusRUO

FPR2, also known as ALX/FPR2, is a G protein-coupled receptor with dual roles in pro- and anti-inflammatory signaling. It is expressed on neutrophils, macrophages, and epithelial cells, where it recognizes formylated peptides, lipoxin A4, and other endogenous or pathogen-derived ligands. FPR2 signaling activates pathways like PI3K/Akt and MAPK, regulating immune cell chemotaxis, phagocytosis, and cytokine production. Uniquely, FPR2 mediates both inflammatory responses and resolution of inflammation, depending on the ligand. For example, it promotes inflammation in response to bacterial peptides but facilitates resolution through lipoxin A4, which reduces neutrophil recruitment and promotes tissue repair. Dysregulation of FPR2 is linked to chronic inflammation, autoimmune diseases, and sepsis. In cancer, FPR2 can either support or inhibit tumor progression by influencing immune cell behavior and tumor microenvironment composition. FPR2’s ability to switch between pro- and anti-inflammatory states highlights its therapeutic potential for modulating inflammation, resolving chronic inflammatory diseases, and targeting immune dysfunction in cancer.

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