Mouse FIL1d(Interleukin 1 Delta) ELISA Kit

Este producto es parte de IL36RN - Interleukin-36 receptor antagonist protein
Mouse FIL1d(Interleukin 1 Delta) ELISA Kit

Pida mas información

935106861

info@markelab.com

Precio

Precio a consultar

Elisa Kits IL36RN

proveedor

FineTest

reference

EM1025

Tested Applications

reactivity

mouse

status

RUO

clonality


Background

IL36RN, also known as IL-36Ra, is an anti-inflammatory cytokine that functions as a natural inhibitor of IL-36 signaling. It binds to the IL-36 receptor (IL1RL2) and prevents its activation by IL36A, IL36B, and IL36G, thereby blocking downstream NF-κB, MAPK, and JNK signaling pathways. IL36RN is primarily expressed in keratinocytes, epithelial cells, and immune cells, where it regulates inflammation and prevents excessive immune activation at epithelial barriers. It plays a key role in maintaining tissue homeostasis and limiting pathological inflammation in conditions such as psoriasis, where mutations in IL36RN lead to uncontrolled IL-36 activity, severe inflammation, and pustular psoriasis. IL36RN is also implicated in mucosal immunity and inflammatory diseases of the skin, lungs, and gastrointestinal tract. Knockout studies reveal heightened IL-36 signaling, excessive cytokine production, and severe tissue inflammation, underscoring IL36RN's role as a key anti-inflammatory regulator and protective factor in immune homeostasis and barrier tissue health.

Características del producto

category

ELISA Kits


reactivity

mouse


test range

31.25-2000pg/ml


assay type

Sandwich ELISA, Double Antibody


assay data

Quantitative


detection method

Colorimetric


sample type

Serum,Plasma,Tissue homogenates,Other biological fluids


size 1

96T


alias

IL-36Ra,IL-1F5,FIL1, FIL1Delta,IL1F5


storage

2-8 °C for 6 months


or code

IL36RN


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