Mouse Fibroblast Growth Factor Receptor Substrate 2 (FRS2) ELISA Kit

Este producto es parte de FRS - Fibroblast growth factor receptor substrate
Mouse Fibroblast Growth Factor Receptor Substrate 2 (FRS2) ELISA Kit

Pida mas información

935106861

info@markelab.com

Precio

546€ (96 tests)

Elisa kits for FRS2

proveedor

Abbexa

reference

abx254085

Tested Applications

ELISA

reactivity

Mouse

status

RUO

clonality

Descripción

Mouse Fibroblast Growth Factor Receptor Substrate 2 (FRS2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Fibroblast Growth Factor Receptor Substrate 2 (FRS2) concentrations in tissue homogenates, cell lysates and other biological fluids.


Background

Fibroblast growth factor receptor substrate 2 (FRS2) is an intracellular adaptor protein that plays a pivotal role in the signaling pathways of fibroblast growth factor receptors (FGFRs). Upon FGFR activation, FRS2 becomes tyrosine-phosphorylated and acts as a docking platform for various signaling molecules. It primarily facilitates the recruitment of Grb2 and Sos, leading to the activation of the Ras/MAPK pathway, which is essential for cell proliferation, differentiation, and survival. FRS2 also interacts with Shp2, linking FGFR activation to the phosphatidylinositol 3-kinase (PI3K) pathway, which regulates cell survival and metabolic processes. FRS2 is highly involved in developmental processes and is often implicated in diseases such as cancer, where FGFR signaling is dysregulated. Its role as a signaling hub makes it a critical component in cellular communication and a potential target for therapeutic interventions in FGFR-related disorders.

Características del producto

category

ELISA Kits


immunogen target

Fibroblast Growth Factor Receptor Substrate 2 (FRS2)


reactivity

Mouse


test range

7.81 pg/ml - 500 pg/ml


sensitivity

4.69 pg/ml


assay type

Sandwich


assay data

Quantitative


form

Lyophilized


detection method

Colorimetric


sample type

Tissue homogenates, cell lysates and other biological fluids.


size 1

96 tests


size 2

5 × 96 tests


size 3

10 × 96 tests


alias

FRS2A, FRS2alpha, SNT, SNT-1, SNT1, FRS1A,FGFR substrate 2,FGFR-signaling adaptor SNT


storage

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.


or code

FRS2


dry ice

No


note

This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.


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