Mouse Fc Fragment of IgG, Low Affinity IIb, Receptor For (CD32) (FCGR2B) Protein (Biotin) (Active)
897€ (20 µg)
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935106861
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name
Mouse Fc Fragment of IgG, Low Affinity IIb, Receptor For (CD32) (FCGR2B) Protein (Biotin) (Active)
category
Proteins and Peptides
provider
Abbexa
reference
abx692684
tested applications
SDS-PAGE
Description
Mouse CD32 Protein (Biotin) is a recombinant protein from Mouse produced in HEK293 Cells. A DNA sequence encoding the extracellular domain (Met 1-Arg 217) of mouse FGGR2B (NP_001070657.1) as fused with a c-terminal polyhistidine tagged AVI tag at the C-terminus. The expressed protein was biotinylated in vivo by the Biotin-Protein ligase (BirA enzyme) which is co-expressed.
Documents del producto
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Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | CD32 (Biotin) |
| Host | HEK293 cells |
| Origin | Mouse |
| Conjugation | Biotin |
| Observed MW | Molecular Weight: 23.9 kDa Sequence Fragment: Met1-Arg217 Tag: C-terminal His tag and AVI tag Validity: The validity for this protein is 12 months. |
| Expression | Recombinant |
| Purity | > 97% (SDS-PAGE) |
| Size 1 | 20 µg |
| Size 2 | 100 µg |
| Form | |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile PBS, pH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | NP_001070657.1 |
| Alias | CD32,FCG2,CD32B,FCGR2,IGFR2,FCGR2C,FcGRIIB,FcRII-c,FcgammaRIIb,Low affinity immunoglobulin gamma Fc region receptor II-b,IgG Fc receptor II-b,CDw32,Fc-gamma RII-b |
| Background | Protein FCGR2B |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
FCGR2B (Fc gamma receptor IIB), also known as CD32B, is a low-affinity receptor for the Fc portion of IgG antibodies, primarily responsible for regulating immune responses by mediating inhibitory signaling. It plays a crucial role in the balance between activation and inhibition of immune cells, preventing excessive inflammation and autoimmunity. Unlike its closely related receptor, FCGR2A, which triggers activating signals, FCGR2B is the only inhibitory receptor within the Fc gamma receptor family. This receptor is predominantly expressed on B cells, dendritic cells, macrophages, and other immune cells. FCGR2B is part of the larger family of Fc gamma receptors (FcγRs), which bind the Fc region of immunoglobulin G (IgG) to mediate immune responses such as phagocytosis, cytokine release, and the clearance of immune complexes. Its inhibitory role is vital in the prevention of autoimmune reactions and the modulation of inflammatory responses.
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