Mouse Damage Specific DNA Binding Protein 2 (DDB2) Protein

Este producto es parte de DDB - damage specific DNA binding protein
Mouse Damage Specific DNA Binding Protein 2 (DDB2) Protein

Pida mas información

935106861

info@markelab.com

Precio

234€ (10 µg)

Protein DDB2

proveedor

Abbexa

reference

abx166155

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Damage Specific DNA Binding Protein 2 is a recombinant Mouse protein expressed in E. coli.


Background

Damage-specific DNA binding protein 2 (DDB2) is a substrate recognition protein that works in concert with DDB1 within the UV-DDB complex, a subset of the CUL4-DDB1 E3 ubiquitin ligase system. DDB2 plays an essential role in nucleotide excision repair (NER) by recognizing UV-induced DNA damage, such as cyclobutane pyrimidine dimers (CPDs) and 6-4 photoproducts, and recruiting repair factors to the damage site. Its high affinity for damaged DNA and ability to induce chromatin remodeling are key to facilitating repair processes. DDB2 also mediates the ubiquitination and degradation of histones and other chromatin-associated proteins, promoting access to damaged DNA. Mutations or dysregulation of DDB2 have been linked to xeroderma pigmentosum group E (XP-E), a condition characterized by extreme sensitivity to UV light and a high predisposition to skin cancer. Beyond DNA repair, DDB2 is implicated in cell cycle regulation and apoptosis, highlighting its multifunctional role in maintaining genomic integrity.

Características del producto

category

Proteins and Peptides


origin

Mouse


host

E. coli


immunogen target

Damage Specific DNA Binding Protein 2 (DDB2)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 26.0 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Lys212-Leu407 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

DDB2


dry ice

No


availability

Shipped within 5-7 working days.


alias

XPE,DDBB,UV-DDB2,UV-damaged DNA-binding protein 2,Damage-specific DNA-binding protein 2,DDB p48 subunit


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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