Mouse Contactin 2 (CNTN2) Protein

Product specifications

Proteins and Peptides

Contactin 2 (CNTN2)

E. coli

Mouse

Unconjugated

Molecular Weight: Calculated MW: 26.2 kDa
Concentration: Prior to lyophilization: 200 µg/ml
Sequence Fragment: Ser802-Thr1008
Tag: N-terminal His tag

Recombinant

> 95%

10 µg

50 µg

100 µg

200 µg

500 µg

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.

WB, SDS-PAGE

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.

Shipped within 5-7 working days.

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.

No

Q61330

AXT,TAX,TAX1,EPEO5,FAME5,TAG-1,Transient axonal glycoprotein 1,Axonin-1,Axonal glycoprotein TAG-1,Contactin-2

Protein CNTN2

RUO

This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

Contactin 2 (CNTN2), also known as TAG-1 (Transient Axonal Glycoprotein 1), is another GPI-anchored neural adhesion molecule involved in axonal guidance, synaptic development, and neuron-glia interactions. CNTN2 is predominantly expressed during development in the central and peripheral nervous systems, where it plays a critical role in axon fasciculation, neurite outgrowth, and myelination. It interacts with receptors such as L1CAM, Caspr2, and other contactins to promote the formation of functional neural circuits. CNTN2 is also implicated in the organization of nodes of Ranvier, where it stabilizes interactions between axons and myelinating glial cells. Genetic studies have linked CNTN2 mutations to neurodevelopmental and neuropsychiatric disorders, including autism and epilepsy, where its dysregulation disrupts neural connectivity and excitability. It has also been studied in the context of autoimmune diseases like multiple sclerosis, where anti-CNTN2 antibodies contribute to neuroinflammation and demyelination. Structurally, CNTN2 shares immunoglobulin-like and fibronectin type III domains with other contactins, allowing it to mediate dynamic and specific cell-cell interactions in the nervous system.

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