Mouse Constitutive Androstane Receptor / CAR (NR1I3) Protein
221€ (10 µg)
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Name
Mouse Constitutive Androstane Receptor / CAR (NR1I3) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx168959
Tested Applications
WB, SDS-PAGE
Description
Mouse CAR Protein is a recombinant Mouse protein expressed in E. coli.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Constitutive Androstane Receptor / CAR (NR1I3) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Met1-Glu247 Tag: N-terminal His tag |
| Origin | Mouse |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 31.8 kDa Observed MW (SDS-PAGE): 32 kDa |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01%Sarcosyl, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Dry Ice | No |
| UniProt ID | O35627 |
| Alias | CAR,CAR1,MB67,Constitutive activator of retinoid response,Orphan nuclear receptor MB67 |
| Background | Protein NR1I3 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. Concentration: Prior to lyophilization: 200 µg/ml |
Background
Nuclear receptor subfamily 1 group I member 3 (NR1I3), also known as the constitutive androstane receptor (CAR), is a nuclear receptor involved in regulating the metabolism of xenobiotics, drugs, and endogenous compounds CAR is activated by various ligands, including drugs, steroids, and bile acids, and it modulates the expression of genes involved in detoxification and drug metabolism It is primarily expressed in the liver, intestine, and kidneys, where it controls the transcription of genes that enhance the metabolism and clearance of toxins, carcinogens, and drugs CAR plays a key role in regulating liver function, bile acid homeostasis, and the metabolism of fatty acids In addition to its role in detoxification, CAR has been implicated in the regulation of inflammation and immune responses Dysregulation of CAR can contribute to liver disease, altered drug metabolism, and drug toxicity, making it an important receptor for understanding drug interactions and developing strategies to manage liver disorders and improve drug safety
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