Mouse Complement Component C3a Receptor (C3AR1) ELISA Kit
715€ (96 tests)
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name
Mouse Complement Component C3a Receptor (C3AR1) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx392273
tested applications
ELISA
Description
Mouse Complement Component C3a Receptor (C3AR1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Complement Component C3a Receptor (C3AR1) concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Complement Component C3a Receptor (C3AR1) |
| Reactivity | Mouse |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 78 pg/ml - 5000 pg/ml |
| Sensitivity | < 46.9 pg/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-12 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | O09047 |
| Gene ID | 12267 |
| Alias | C3AR1,C3AR,C3a anaphylatoxin chemotactic receptor,C3a-R,anaphylatoxin C3a receptor,complement component 3a receptor,C3a receptor,AZ3B,HNFAG09 |
| Background | Elisa kits for C3AR1 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
C3AR1 is a G protein-coupled receptor that binds C3a, a complement system-derived anaphylatoxin, playing a pivotal role in inflammation and immune responses. C3AR1 is widely expressed on immune cells, including neutrophils, macrophages, eosinophils, and mast cells, where it mediates chemotaxis, degranulation, and cytokine production in response to C3a binding. It is a key regulator of the complement system, promoting immune cell recruitment and activation during infections, injury, and inflammatory responses. C3AR1 signaling activates pathways such as PI3K/Akt and ERK, driving cellular responses that contribute to host defense. Dysregulated C3AR1 activity is implicated in inflammatory and autoimmune diseases, including rheumatoid arthritis, asthma, and sepsis, where excessive complement activation exacerbates tissue damage and inflammation. In cancer, C3AR1 expression on tumor-associated macrophages and other immune cells modulates the tumor microenvironment, promoting immunosuppression and angiogenesis. C3AR1 is also involved in neuroinflammation, contributing to neurodegenerative diseases like Alzheimer’s and multiple sclerosis by mediating microglial activation and cytokine release. Therapeutically, targeting C3AR1 with inhibitors or antagonists is being explored to modulate complement-driven inflammation and reduce tissue damage in autoimmune diseases and cancer.
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