Mouse Complement Component 5a Receptor 1 (C5AR1) Protein

Product specifications

Proteins and Peptides

Complement Component 5a Receptor 1 (C5AR1)

E. coli

Mouse

Unconjugated

Concentration: Prior to lyophilization: 200 µg/ml
Sequence Fragment: Please enquire.
Tag: N-terminal His tag

Recombinant

> 90%

1 mg

5 mg

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.

WB, SDS-PAGE

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.

Shipped within 1-2 months.

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.

No

C5AR1,CD88,C5A,C5AR,C5R1,C5a anaphylatoxin chemotactic receptor,C5a-R,complement C5a receptor,complement component 5a receptor 1

Protein C5AR1

RUO

This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

C5AR1 is a G protein-coupled receptor (GPCR) that binds C5a, a potent anaphylatoxin generated during complement activation, playing a key role in immune responses and inflammation. C5AR1 is primarily expressed on immune cells, including neutrophils, macrophages, eosinophils, and mast cells, where its activation triggers chemotaxis, degranulation, and the release of pro-inflammatory cytokines. The receptor mediates downstream signaling pathways, such as PI3K/Akt, MAPK, and NF-κB, promoting cell migration, survival, and inflammatory responses. C5AR1 is crucial for host defense, facilitating immune cell recruitment to sites of infection and tissue damage. However, dysregulated C5AR1 signaling contributes to excessive inflammation in diseases such as sepsis, rheumatoid arthritis, and asthma. In cancer, C5AR1 modulates the tumor microenvironment by promoting the recruitment of immunosuppressive myeloid cells, facilitating tumor growth and immune evasion. Additionally, C5AR1 activation has been implicated in neuroinflammation, contributing to neurodegenerative diseases like Alzheimer’s. Therapeutic targeting of C5AR1 with antagonists or inhibitors is being explored to treat inflammatory diseases, autoimmune disorders, and complement-driven cancers, aiming to reduce excessive inflammation and immune dysfunction.

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Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a(PubMed:1847994, PubMed:8182049, PubMed:7622471, PubMed:9553099, PubMed:10636859, PubMed:15153520). The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events(PubMed:8182049, PubMed:7622471, PubMed:9553099). Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production(PubMed:10636859, PubMed:15153520).

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