Mouse Cluster Of Differentiation 14 (CD14) Protein

Este producto es parte de CD14 - Cluster of Differentiation 14
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1079€ (100 µg)

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935106861
info@markelab.com
name
Mouse Cluster Of Differentiation 14 (CD14) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx692712
tested applications
SDS-PAGE

Description

Mouse CD14 Protein is a recombinant protein from Mouse produced in HEK293 Cells. A DNA sequence encoding the extracellular domain (Met 1-Pro 345) of mouse CD14 (NP_033971.1) precursor was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Proteins and Peptides
Immunogen Target
CD14
Host
HEK293 cells
Origin
Mouse
Observed MW
Molecular Weight: 63.5 kDa
Sequence Fragment: Met1-Pro345
Tag: C-terminal His tag and Fc tag
Validity: The validity for this protein is 12 months.
Expression
Recombinant
Purity
> 97% (SDS-PAGE)
Size 1
100 µg
Form
 
Tested Applications
SDS-PAGE
Buffer
Lyophilized from sterile PBS, pH 7.4.
Availability
Shipped within 5-15 working days.
Storage
Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
NCBI Accession
NP_033971.1
Alias
Cluster Of Differentiation 14,CD14,Myeloid Cell-Specific Leucine-Rich Glycoprotein,Monocyte differentiation antigen CD14
Background
Protein CD14
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

CD14 is a pattern recognition receptor (PRR) expressed on the surface of monocytes, macrophages, and neutrophils, where it plays a key role in the innate immune response CD14 functions as a co-receptor for the detection of lipopolysaccharides (LPS) derived from the outer membrane of Gram-negative bacteria It forms a complex with LPS-binding protein (LBP) and transduces signals via the Toll-like receptor 4 (TLR4)-MD2 complex, initiating downstream activation of nuclear factor kappa B (NF-κB) and subsequent production of pro-inflammatory cytokines CD14 exists in two forms, a membrane-bound form (mCD14) and a soluble form (sCD14), both of which contribute to LPS recognition and systemic inflammatory responses Dysregulation of CD14 signaling has been implicated in sepsis, chronic inflammatory diseases, and autoimmune disorders Elevated levels of soluble CD14 serve as a biomarker for monocyte activation in conditions such as HIV, cardiovascular disease, and metabolic disorders

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