Mouse Cluster Of Differentiation 14 (CD14) Protein
897€ (100 µg)
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name
Mouse Cluster Of Differentiation 14 (CD14) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx691925
tested applications
SDS-PAGE
Description
Mouse CD14 Protein is a recombinant protein from Mouse produced in HEK293 Cells. A DNA sequence encoding the extracellular domain (Met 1-Pro 345) of mouse CD14 (NP_033971.1) precursor was fused with a polyhistidine tag at the C-terminus.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | CD14 |
| Host | HEK293 cells |
| Assay Type | Activity: Not tested Sequence Fragment: Met1-Pro345 Tag: C-terminal His tag |
| Origin | Mouse |
| Observed MW | 36.8 kDa |
| Expression | Recombinant |
| Purity | > 97% (SDS-PAGE) |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile PBS, pH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Storage: Store lyophilized between -20 °C and -80°C. Stability: Stable when stored reconstituted at 2-8°C for up to 1 week. Reconstituted aliquots are stable at -20°C for up to 3 months. Shelf Life: 12 months. |
| Dry Ice | No |
| NCBI Accession | NP_033971.1 |
| Alias | Cluster Of Differentiation 14,CD14,Myeloid Cell-Specific Leucine-Rich Glycoprotein,Monocyte differentiation antigen CD14 |
| Background | Protein CD14 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Endotoxin Level: < 1.0 EU per µg (LAL method). |
Descripción
CD14 is a pattern recognition receptor (PRR) expressed on the surface of monocytes, macrophages, and neutrophils, where it plays a key role in the innate immune response CD14 functions as a co-receptor for the detection of lipopolysaccharides (LPS) derived from the outer membrane of Gram-negative bacteria It forms a complex with LPS-binding protein (LBP) and transduces signals via the Toll-like receptor 4 (TLR4)-MD2 complex, initiating downstream activation of nuclear factor kappa B (NF-κB) and subsequent production of pro-inflammatory cytokines CD14 exists in two forms, a membrane-bound form (mCD14) and a soluble form (sCD14), both of which contribute to LPS recognition and systemic inflammatory responses Dysregulation of CD14 signaling has been implicated in sepsis, chronic inflammatory diseases, and autoimmune disorders Elevated levels of soluble CD14 serve as a biomarker for monocyte activation in conditions such as HIV, cardiovascular disease, and metabolic disorders
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