Mouse Cleavage stimulation factor subunit 2 (CSTF2) ELISA Kit

Este producto es parte de CSTF - cleavage stimulation factor subunit
Product Graph
715€ (96 tests)

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.

935106861
info@markelab.com
name
Mouse Cleavage stimulation factor subunit 2 (CSTF2) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx508952
tested applications
ELISA

Description

Mouse Cleavage stimulation factor subunit 2 (CSTF2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Cleavage stimulation factor subunit 2 concentrations in tissue homogenates, cell lysates and other biological fluids.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
ELISA Kits
Immunogen Target
Cleavage stimulation factor subunit 2 (CSTF2)
Reactivity
Mouse
Detection Method
Colorimetric
Assay Data
Quantitative
Test Range
0.156 ng/ml - 10 ng/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Form
Lyophilized
Tested Applications
ELISA
Sample Type
Tissue homogenates, cell lysates and other biological fluids.
Availability
Shipped within 5-15 working days. The validity for this kit is 6 months.
Storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
UniProt ID
Q8BIQ5
Gene ID
108062
Alias
CSTF64,CstF-64,XLID113,Cleavage stimulation factor 64 kDa subunit,CF-1 64 kDa subunit
Background
Elisa kits for CSTF2
Status
RUO
Note
Validity: The validity for this kit is 6 months.
This product is for research use only.   The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.   Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

Cleavage stimulation factor subunit 2 (CSTF2) is a critical component of the cleavage stimulation factor (CstF) complex, required for the 3' end processing of pre-mRNAs through cleavage and polyadenylation. CSTF2 contains an RNA recognition motif (RRM) that specifically binds to GU-rich elements downstream of the cleavage site, ensuring accurate mRNA maturation and stability. CSTF2 interacts with CSTF1 and CSTF3 to form the heterotrimeric CstF complex, which assembles on the pre-mRNA substrate to facilitate the recruitment of other cleavage factors. Its expression is cell-cycle regulated, with levels peaking during the transition from G0 to S phase, indicating its role in cell proliferation and growth. CSTF2 also influences alternative polyadenylation, a process that regulates mRNA isoform diversity and contributes to cellular differentiation and responses to environmental signals. Dysregulation of CSTF2 has been associated with oncogenic processes, such as 3' UTR shortening in cancer cells, which can enhance the stability and translation of growth-promoting mRNAs, underscoring its significance in both normal physiology and pathology.

Related Products

EH4714

Human CSTF2 (Cleavage stimulation factor subunit 2) ELISA Kit

Ver Producto
QT-EH4714

Human CSTF2 (Cleavage stimulation factor subunit 2) QuickTest ELISA Kit

Ver Producto
abx006066

Cleavage Stimulation Factor Subunit 2 (CSTF2) Antibody

CSTF2 Antibody is a Rabbit Polyclonal Antibody against CSTF2.

Ver Producto