Mouse Chemokine C-C-Motif Receptor 1 / CD191 (CCR1) Protein

Product specifications

Proteins and Peptides

Chemokine C-C-Motif Receptor 1 / CD191 (CCR1)

E. coli

Mouse

Unconjugated

Concentration: Prior to lyophilization: 200 µg/ml
Sequence Fragment: Please enquire.
Tag: N-terminal His tag

Recombinant

> 90%

1 mg

5 mg

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.

WB, SDS-PAGE

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.

Shipped within 1-2 months.

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.

No

CCR1,CC CKR1,CKR1,MIP-1αR,CD191,MIP1aR,CKR-1,HM145,CMKBR1,MIP1aR,SCYAR1,Chemokine C-C-Motif Receptor 1

Protein CCR1

RUO

This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

C-C Chemokine Receptor Type 1 (CCR1) is a G-protein-coupled receptor (GPCR) primarily expressed on the surface of immune cells such as monocytes, macrophages, T lymphocytes, neutrophils, and eosinophils. CCR1 binds C-C chemokines, including CCL3 (MIP-1α), CCL5 (RANTES), and CCL14, driving immune cell chemotaxis, activation, and trafficking to sites of inflammation, infection, or tissue damage. This receptor plays a central role in the innate immune response and facilitates the migration of immune cells to areas where pathogens or damaged tissues trigger inflammatory signals. CCR1 signaling activates pathways such as MAPK, PI3K/AKT, and NF-κB, leading to cytokine secretion, increased cell adhesion, and immune cell recruitment. Dysregulated CCR1 activity is implicated in autoimmune diseases such as rheumatoid arthritis, multiple sclerosis, and inflammatory bowel disease (IBD), where excessive recruitment of leukocytes amplifies inflammation and tissue damage. CCR1 also contributes to the pathogenesis of certain cancers, as its activation promotes tumor progression, angiogenesis, and metastasis by recruiting immune cells to the tumor microenvironment. Therapeutic strategies targeting CCR1, including small molecule antagonists and antibodies, are being developed to treat chronic inflammatory conditions and prevent tumor-associated immune infiltration. Research continues to uncover its role in infection, immunity, and cancer, highlighting its importance as a therapeutic target in immune-mediated diseases and oncology.

Related Products

Bovine CCR1 (C-C chemokine receptor type 1) ELISA Kit

Ver Producto

Human Chemokine C-C-Motif Receptor 1 / CD191 (CCR1) ELISA Kit

Human Chemokine C-C-Motif Receptor 1 / CD191 (CCR1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Chemokine C-C-Motif Receptor 1 / CD191 (CCR1) concentrations in tissue homogenates, cell lysates and other biological fluids. This assay has high sensitivity and excellent specificity for detection of Chemokine C-C-Motif Receptor 1 (CCR1)

Ver Producto

Mouse Chemokine C-C-Motif Receptor 1 / CD191 (CCR1) ELISA Kit

Mouse Chemokine C-C-Motif Receptor 1 / CD191 (CCR1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Chemokine C-C-Motif Receptor 1 / CD191 (CCR1) concentrations in tissue homogenates, cell lysates and other biological fluids. This assay has high sensitivity and excellent specificity for detection of Chemokine C-C-Motif Receptor 1 (CCR1)

Ver Producto