Mouse Chemokine C-C-Motif Receptor 1 / CD191 (CCR1) ELISA Kit
643.5€ (96 tests)
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name
Mouse Chemokine C-C-Motif Receptor 1 / CD191 (CCR1) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx153792
tested applications
ELISA
Description
Mouse Chemokine C-C-Motif Receptor 1 / CD191 (CCR1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Chemokine C-C-Motif Receptor 1 / CD191 (CCR1) concentrations in tissue homogenates, cell lysates and other biological fluids. This assay has high sensitivity and excellent specificity for detection of Chemokine C-C-Motif Receptor 1 (CCR1)
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Chemokine C-C-Motif Receptor 1 / CD191 (CCR1) |
| Reactivity | Mouse |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Sensitivity | < 0.06 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-7 working days. The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | CCR1,CC CKR1,CKR1,MIP-1αR,CD191,MIP1aR,CKR-1,HM145,CMKBR1,MIP1aR,SCYAR1,Chemokine C-C-Motif Receptor 1 |
| Background | Elisa kits for CCR1 |
| Status | RUO |
| Note | Validity: The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
C-C Chemokine Receptor Type 1 (CCR1) is a G-protein-coupled receptor (GPCR) primarily expressed on the surface of immune cells such as monocytes, macrophages, T lymphocytes, neutrophils, and eosinophils. CCR1 binds C-C chemokines, including CCL3 (MIP-1α), CCL5 (RANTES), and CCL14, driving immune cell chemotaxis, activation, and trafficking to sites of inflammation, infection, or tissue damage. This receptor plays a central role in the innate immune response and facilitates the migration of immune cells to areas where pathogens or damaged tissues trigger inflammatory signals. CCR1 signaling activates pathways such as MAPK, PI3K/AKT, and NF-κB, leading to cytokine secretion, increased cell adhesion, and immune cell recruitment. Dysregulated CCR1 activity is implicated in autoimmune diseases such as rheumatoid arthritis, multiple sclerosis, and inflammatory bowel disease (IBD), where excessive recruitment of leukocytes amplifies inflammation and tissue damage. CCR1 also contributes to the pathogenesis of certain cancers, as its activation promotes tumor progression, angiogenesis, and metastasis by recruiting immune cells to the tumor microenvironment. Therapeutic strategies targeting CCR1, including small molecule antagonists and antibodies, are being developed to treat chronic inflammatory conditions and prevent tumor-associated immune infiltration. Research continues to uncover its role in infection, immunity, and cancer, highlighting its importance as a therapeutic target in immune-mediated diseases and oncology.
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