Mouse CD27 Antigen / TNFRSF7 (CD27) Protein (Active)
1235€ (100 µg)
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935106861
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name
Mouse CD27 Antigen / TNFRSF7 (CD27) Protein (Active)
category
Proteins and Peptides
provider
Abbexa
reference
abx692693
tested applications
SDS-PAGE
Description
Mouse CD27 Protein is a recombinant protein from Mouse produced in HEK293 Cells. A DNA sequence encoding the extracellular domain (Met 1-Arg 182) of mouse CD27 (NP_001028298.1) precursor was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | CD27 |
| Host | HEK293 cells |
| Origin | Mouse |
| Observed MW | Molecular Weight: 46.2 kDa Sequence Fragment: Met1-Arg182 Tag: C-terminal His tag and Fc tag Validity: The validity for this protein is 12 months. |
| Expression | Recombinant |
| Purity | > 94% (SDS-PAGE) |
| Size 1 | 100 µg |
| Form | |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile PBS, pH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | NP_001028298.1 |
| Alias | T14,S152,Tp55,TNFRSF7,CD27 antigen,CD27L receptor,T-cell activation antigen CD27,Tumor necrosis factor receptor superfamily member 7 |
| Background | Protein CD27 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
CD27, also known as TNFRSF7 (tumor necrosis factor receptor superfamily member 7), is a cell surface receptor primarily expressed on T cells, B cells, and NK cells, playing a pivotal role in the regulation of immune responses. CD27 is a member of the TNF receptor superfamily and functions as a key co-stimulatory molecule, contributing to the development and survival of T lymphocytes, the formation of memory T cells, and the activation of B cells. Its ligand, CD70, also plays an essential role in immune activation, particularly in T-cell-B-cell communication. CD27 engagement through CD70 induces signaling pathways critical for T-cell activation, proliferation, differentiation, and long-term immune memory. The CD27-CD70 axis is tightly regulated because dysregulation of these pathways can lead to immune system-related diseases, including autoimmune disorders, chronic inflammation, and cancer. In addition to its role in adaptive immunity, CD27 is involved in immune surveillance and the elimination of pathogens and tumor cells. Importantly, CD27 is a target for therapeutic intervention, particularly in immunotherapy strategies aimed at boosting the immune response against cancer.
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