Mouse Cartilage Oligomeric Matrix Protein (COMP) Protein

Este producto es parte de COMP - Cartilage Oligomeric Matrix Protein
Mouse Cartilage Oligomeric Matrix Protein (COMP) Protein

Pida mas información

935106861

info@markelab.com

Precio

221€ (10 µg)

Protein COMP

proveedor

Abbexa

reference

abx065738

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Recombinant Cartilage Oligomeric Matrix Protein (COMP) is a recombinant Mouse protein produced in a Prokaryotic expression system (E. coli).


Background

COMP is a non-collagenous extracellular matrix protein primarily expressed in cartilage, tendons, and ligaments where it plays a key role in maintaining tissue structure and mechanical integrity COMP interacts with collagen fibrils and other matrix components to facilitate fibril assembly and stabilize the extracellular matrix COMP also functions as a chaperone during collagen secretion, promoting proper folding and export from chondrocytes Mutations in COMP are associated with skeletal dysplasias such as pseudoachondroplasia and multiple epiphyseal dysplasia, which result in abnormal cartilage development, joint pain, and short stature COMP overexpression has been observed in osteoarthritis and rheumatoid arthritis, where its elevated levels contribute to cartilage degradation and inflammation COMP is also implicated in cardiovascular diseases where it regulates vascular smooth muscle cell function and extracellular matrix remodeling

Características del producto

category

Proteins and Peptides


origin

Mouse


host

E. coli


immunogen target

Cartilage Oligomeric Matrix Protein (COMP)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 24.5 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Gln554-Gln753 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

COMP


dry ice

No


availability

Shipped within 5-12 working days.


alias

MED,CTS2,EDM1,EPD1,TSP5,PSACH,THBS5,TSP-5,Thrombospondin-5


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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