Mouse C-Type Lectin Domain Family 4, Member L (CLEC4L) Protein

Este producto es parte de CD209 - CD209 molecule
Mouse C-Type Lectin Domain Family 4, Member L (CLEC4L) Protein
221€ (10 µg)

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Name
Mouse C-Type Lectin Domain Family 4, Member L (CLEC4L) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx168718
Tested Applications
WB, SDS-PAGE

Description

Mouse CLEC4L Protein is a recombinant Mouse protein expressed in E. coli.

Documentos del producto

Instrucciones
Data sheet
Descargar

Especificaciones del producto

Category
Proteins and Peptides
Immunogen Target
C-Type Lectin Domain Family 4, Member L (CLEC4L)
Host
E. coli
Assay Type
Activity: Not tested
Sequence Fragment: Phe115-Lys238
Tag: N-terminal His tag
Origin
Mouse
Conjugation
Unconjugated
Observed MW
Calculated MW: 18.0 kDa  Observed MW (SDS-PAGE): 18 kDa
Expression
Recombinant
Purity
> 95%
Size 1
10 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
500 µg
Form
Lyophilized
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-7 working days.
Storage
Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles.
Dry Ice
No
UniProt ID
Q91ZX1
Alias
C-type lectin domain family 4 member L,CDSIGN,CLEC4L,DC-SIGN,DC-SIGN1,hDC-SIGN,Dendritic cell-specific ICAM-3-grabbing non-integrin 1,CD209 antigen
Background
Protein CD209
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Concentration: Prior to lyophilization: 200 µg/ml

Background

CD209, commonly known as DC-SIGN (Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin), is a type II transmembrane protein receptor primarily expressed on the surface of dendritic cells (DCs) and some macrophage subsets. It plays a crucial role in the immune system by mediating pathogen recognition, cellular adhesion, and antigen capture. CD209 is a member of the C-type lectin receptor (CLR) family and exhibits high affinity for mannose-rich glycans, a feature that enables it to bind to a range of microbial structures, facilitating the immune response against pathogens. One of CD209's defining characteristics is its ability to recognize pathogen-associated molecular patterns (PAMPs), which are specific carbohydrate patterns on pathogens. By binding to these patterns, CD209 captures and internalizes pathogens, aiding in their processing and subsequent antigen presentation to T cells. The receptor is particularly relevant in the context of HIV, Mycobacterium tuberculosis, Ebola, and Dengue virus, as it can interact with these pathogens and contribute to their immune response or facilitate viral entry in certain cases.

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