Mouse C-C Chemokine Receptor Type 8 (CCR8) ELISA Kit
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Description
Mouse C-C Chemokine Receptor Type 8 (CCR8) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse C-C Chemokine Receptor Type 8 (CCR8) concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | C-C Chemokine Receptor Type 8 (CCR8) |
| Reactivity | Mouse |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.312 ng/ml - 20 ng/ml |
| Sensitivity | 0.19 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-7 working days. The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | P56484 |
| Gene ID | 12776 |
| Alias | CCR8,C-C motif chemokine receptor 8,ChemR1,CKR-L1,TER1,GPR-CY6,CC-CKR-8,CCR-8,CDw198,CKRL1,CMKBR8,CMKBRL2,CY6,GPRCY6,TER1 |
| Background | Elisa kits for CCR8 |
| Status | RUO |
| Note | Validity: The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
C-C Chemokine Receptor Type 8 (CCR8) is a G-protein-coupled receptor expressed predominantly on T-helper 2 (Th2) cells, regulatory T cells (Tregs), and subsets of monocytes and dendritic cells. CCR8 interacts primarily with its ligand CCL1, promoting the recruitment and migration of immune cells to inflammatory sites and tissues, particularly in the context of allergic responses and chronic inflammation. CCR8 plays a central role in Th2-mediated immune responses, contributing to diseases such as asthma, atopic dermatitis, and other allergic disorders. In addition, CCR8 is highly expressed on tumor-infiltrating Tregs in the tumor microenvironment, where it fosters immune suppression and allows tumor cells to evade host immunity. Its role in tumor progression and metastasis has made CCR8 an attractive target for cancer immunotherapy. Antibody-based therapies targeting CCR8 are under development to deplete Tregs specifically within tumors, restoring anti-tumor immune responses. CCR8 is also implicated in HIV infection, as it can serve as a co-receptor for the virus, facilitating viral entry into immune cells. Further understanding of CCR8 signaling and its interaction with CCL1 will help develop targeted therapies for allergic diseases, autoimmune conditions, and cancer, making it a versatile and critical player in immune regulation.
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