C-C Chemokine Receptor Type 8 (CCR8) Antibody
195€ (20 µl)
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Name
C-C Chemokine Receptor Type 8 (CCR8) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx006600
Tested Applications
ELISA, WB
Description
CCR8 Antibody is a Rabbit Polyclonal Antibody against CCR8.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: C-C Chemokine Receptor Type 8 (CCR8) Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 296-355 of human CCR8. |
| Host | Rabbit |
| Reactivity | Mouse, Rat |
| Assay Type | Concentration: > 0.2 mg/ml |
| Recommended Dilution | ELISA: 1 µg/ml, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 41 kDa Observed MW: 41 kDa |
| Purification | Purified by affinity chromatography. |
| Size 1 | 20 µl |
| Size 2 | 100 µl |
| Size 3 | 2 × 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P51685 |
| Gene ID | 1237 |
| NCBI Accession | NP_005192.1 |
| Alias | CCR8,C-C motif chemokine receptor 8,ChemR1,CKR-L1,TER1,GPR-CY6,CC-CKR-8,CCR-8,CDw198,CKRL1,CMKBR8,CMKBRL2,CY6,GPRCY6,TER1 |
| Background | Antibody anti-CCR8 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
C-C Chemokine Receptor Type 8 (CCR8) is a G-protein-coupled receptor expressed predominantly on T-helper 2 (Th2) cells, regulatory T cells (Tregs), and subsets of monocytes and dendritic cells. CCR8 interacts primarily with its ligand CCL1, promoting the recruitment and migration of immune cells to inflammatory sites and tissues, particularly in the context of allergic responses and chronic inflammation. CCR8 plays a central role in Th2-mediated immune responses, contributing to diseases such as asthma, atopic dermatitis, and other allergic disorders. In addition, CCR8 is highly expressed on tumor-infiltrating Tregs in the tumor microenvironment, where it fosters immune suppression and allows tumor cells to evade host immunity. Its role in tumor progression and metastasis has made CCR8 an attractive target for cancer immunotherapy. Antibody-based therapies targeting CCR8 are under development to deplete Tregs specifically within tumors, restoring anti-tumor immune responses. CCR8 is also implicated in HIV infection, as it can serve as a co-receptor for the virus, facilitating viral entry into immune cells. Further understanding of CCR8 signaling and its interaction with CCL1 will help develop targeted therapies for allergic diseases, autoimmune conditions, and cancer, making it a versatile and critical player in immune regulation.
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