Mouse Broad Substrate Specificity ATP-Binding Cassette Transporter ABCG2 (ABCG2) Protein

Pida mas información
935106861
info@markelab.com
Precio
221€ (10 µg)
Protein ABCG2
proveedor
Abbexareference
abx168675Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Mouse ABCG2 Protein is a recombinant Mouse protein produced in a Prokaryotic expression system (E. coli).
Background
ABCG2, also known as the breast cancer resistance protein (BCRP), is a well-characterized ATP-binding cassette transporter involved in drug efflux and xenobiotic clearance. It is highly expressed in barrier tissues such as the intestine, liver, kidneys, and blood-brain barrier, where it protects cells by exporting a wide range of substrates, including drugs, toxins, and endogenous metabolites. ABCG2 plays a pivotal role in pharmacokinetics, influencing drug absorption, distribution, and elimination. It is also critical in stem cell biology, where it acts as a marker for side population cells due to its role in drug resistance and dye efflux. Overexpression of ABCG2 is a major contributor to multidrug resistance in cancer, as it actively pumps chemotherapeutic agents out of tumor cells, reducing their efficacy. Structurally, ABCG2 is a half-transporter that forms functional homodimers to mediate ATP-driven substrate transport. Dysregulation of ABCG2 has been linked to diseases such as gout and certain cancers, making it a target of interest in oncology and pharmacology.
Características del producto
category
Proteins and Peptides
origin
Mouse
host
E. coli
immunogen target
Broad Substrate Specificity ATP-Binding Cassette Transporter ABCG2 (ABCG2)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 34.9 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Leu63-Leu349 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
ABCG2
dry ice
No
availability
Shipped within 5-7 working days.
alias
ABC15,ABCP BCRP,BCRP1 BMDP,CD338,CDw338
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
Quizá le pueda interesar
Human ABCG2(ATP-binding cassette sub-family G member 2) ELISA Kit

proveedor
FineTestreference
EH1095reactivity
humanstatus
RUOPrecio a consultar
Ver másRat ABCG2(ATP-binding cassette sub-family G member 2) ELISA Kit

proveedor
FineTestreference
ER1862reactivity
ratstatus
RUOPrecio a consultar
Ver másRecombinant Human ABCG2

proveedor
FineTestreference
P2000Tested Applications
Western Blot, ELISAstatus
RUOPrecio a consultar
Ver más