Mouse Broad Substrate Specificity ATP-Binding Cassette Transporter ABCG2 (ABCG2) Protein

Este producto es parte de ABCG - ATP Binding Cassette Subfamily G
Mouse Broad Substrate Specificity ATP-Binding Cassette Transporter ABCG2 (ABCG2) Protein

Pida mas información

935106861

info@markelab.com

Precio

221€ (10 µg)

Protein ABCG2

proveedor

Abbexa

reference

abx168675

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Mouse ABCG2 Protein is a recombinant Mouse protein produced in a Prokaryotic expression system (E. coli).


Background

ABCG2, also known as the breast cancer resistance protein (BCRP), is a well-characterized ATP-binding cassette transporter involved in drug efflux and xenobiotic clearance. It is highly expressed in barrier tissues such as the intestine, liver, kidneys, and blood-brain barrier, where it protects cells by exporting a wide range of substrates, including drugs, toxins, and endogenous metabolites. ABCG2 plays a pivotal role in pharmacokinetics, influencing drug absorption, distribution, and elimination. It is also critical in stem cell biology, where it acts as a marker for side population cells due to its role in drug resistance and dye efflux. Overexpression of ABCG2 is a major contributor to multidrug resistance in cancer, as it actively pumps chemotherapeutic agents out of tumor cells, reducing their efficacy. Structurally, ABCG2 is a half-transporter that forms functional homodimers to mediate ATP-driven substrate transport. Dysregulation of ABCG2 has been linked to diseases such as gout and certain cancers, making it a target of interest in oncology and pharmacology.

Características del producto

category

Proteins and Peptides


origin

Mouse


host

E. coli


immunogen target

Broad Substrate Specificity ATP-Binding Cassette Transporter ABCG2 (ABCG2)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 34.9 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Leu63-Leu349 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

ABCG2


dry ice

No


availability

Shipped within 5-7 working days.


alias

ABC15,ABCP BCRP,BCRP1 BMDP,CD338,CDw338


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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