Broad Substrate Specificity ATP-Binding Cassette Transporter ABCG2 (ABCG2) Antibody

Descripción

The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters.ABC proteins transport various molecules across extra- and intra-cellular membranes.ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White).This protein is a member of the White subfamily.Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance.It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure.Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue.Tissue specificity: Highly expressed in placenta.Low expression in small intestine, liver and colon.