Mouse Breast Cancer Susceptibility Protein 2 (BRCA2) Protein

Este producto es parte de BRCA2 DNA repair associated
Mouse Breast Cancer Susceptibility Protein 2 (BRCA2) Protein
247€ (10 µg)

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.

Name
Mouse Breast Cancer Susceptibility Protein 2 (BRCA2) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx166162
Tested Applications
WB, SDS-PAGE

Description

Mouse Breast Cancer Susceptibility Protein 2 is a recombinant Mouse protein expressed in E. coli.

Documentos del producto

Instrucciones
Data sheet
Descargar

Especificaciones del producto

Category
Proteins and Peptides
Immunogen Target
Breast Cancer Susceptibility Protein 2 (BRCA2)
Host
E. coli
Assay Type
Activity: Not tested
Sequence Fragment: Glu2990-Ala3232
Tag: N-terminal His tag
Origin
Mouse
Conjugation
Unconjugated
Observed MW
Calculated MW: 30.1 kDa  Observed MW (SDS-PAGE): 30 kDa
Expression
Recombinant
Purity
> 90%
Size 1
10 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
500 µg
Form
Lyophilized
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-7 working days.
Storage
Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles.
Dry Ice
No
Alias
BRCC2,BROVCA2,FACD, FAD,FAD1,FANCD,FANCD1,GLM3,PNCA2,XRCC11,Fanconi anemia group D1 protein
Background
Protein BRCA2
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Concentration: Prior to lyophilization: 200 µg/ml

Background

BRCA2 is a tumor suppressor protein that plays a pivotal role in maintaining genomic stability by facilitating the repair of DNA double-strand breaks through homologous recombination. It interacts with RAD51, a recombinase protein, to mediate the precise alignment and strand exchange during DNA repair. Structurally, BRCA2 contains eight BRC repeats that directly bind RAD51 and a DNA-binding domain that targets damaged DNA regions. Mutations in the BRCA2 gene are strongly associated with an increased risk of hereditary breast, ovarian, and other cancers, such as pancreatic and prostate cancer. These mutations often lead to truncated or dysfunctional proteins, resulting in impaired DNA repair and genomic instability, which drives tumorigenesis. Beyond its role in DNA repair, BRCA2 is also implicated in cell cycle regulation and replication fork protection. BRCA2 deficiency is therapeutically targeted using PARP inhibitors, exploiting synthetic lethality to selectively kill BRCA2-mutant cancer cells while sparing normal cells. This approach has revolutionized treatment options for BRCA2-associated cancers, emphasizing its clinical significance.

Productos relacionados

abx012742

BRCA2 (Phospho-Ser3291) Antibody

Rabbit polyclonal antibody against BRCA2 protein. Immunogen region is C-terminal. Specificity is as follows for the reac…

Ver producto
abx013516

Breast Cancer Type 2 Susceptibility Protein (BRCA2) Antibody

Rabbit polyclonal antibody against BRCA2 protein. Immunogen region is N-terminal.…

Ver producto
abx065607

Human Breast Cancer Susceptibility Protein 2 (BRCA2) Protein

Human Breast Cancer Susceptibility Protein 2 (BRCA2) is a recombinant Human protein expressed in E. coli.…

Ver producto