Mouse BAG Family Molecular Chaperone Regulator 4 (BAG4) Protein

Este producto es parte de BAG - BAG cochaperone 1
Mouse BAG Family Molecular Chaperone Regulator 4 (BAG4) Protein
221€ (10 µg)

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Name
Mouse BAG Family Molecular Chaperone Regulator 4 (BAG4) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx650650
Tested Applications
WB, SDS-PAGE

Description

Mouse BAG4 Protein is a recombinant Mouse protein expressed in E. coli.

Documentos del producto

Instrucciones
Data sheet
Descargar

Especificaciones del producto

Category
Proteins and Peptides
Immunogen Target
BAG Family Molecular Chaperone Regulator 4 (BAG4)
Host
E. coli
Assay Type
Activity: Not tested
Sequence Fragment: Ser210-Ala447
Tag: N-terminal His tag
Origin
Mouse
Conjugation
Unconjugated
Observed MW
Calculated MW: 29.5 kDa
Expression
Recombinant
Purity
> 95%
Size 1
10 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
500 µg
Form
Lyophilized
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-7 working days.
Storage
Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles.
Dry Ice
No
UniProt ID
Q8CI61
Gene ID
67384
Alias
BAG-4,SODD,Bcl-2-associated athanogene 4,Silencer of death domains,BAG family molecular chaperone regulator 4
Background
Protein BAG4
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Concentration: Prior to lyophilization: 200 µg/ml

Background

BAG cochaperone 4 (BAG4), also known as Rem, is a cochaperone that interacts with the HSP70 and HSP90 chaperone proteins to regulate protein folding, degradation, and cellular stress responses BAG4 plays a critical role in managing protein stability and protecting cells from misfolded proteins that can accumulate under stress It is involved in apoptosis regulation, where it interacts with pro-survival signaling pathways to influence cell fate during stress conditions BAG4 also has a significant role in immune cell function and inflammation, where it regulates the degradation of inflammatory signaling molecules and supports immune cell survival under stress Dysregulation of BAG4 has been linked to autoimmune diseases and cancers, where it enhances the stability of oncogenic proteins and prevents apoptotic signaling in tumor cells Additionally, BAG4 is involved in tissue repair and regeneration, particularly in the context of muscle and nervous tissue BAG4’s function in cellular homeostasis, immune regulation, and stress response pathways underscores its importance in maintaining normal cellular function and preventing pathological conditions

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