BAG Family Molecular Chaperone Regulator 4 (BAG4) Antibody
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Description
Rabbit polyclonal antibody against BAG4 protein. Immunogen region is C-terminal.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | BAG Family Molecular Chaperone Regulator 4 (BAG4) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | WB, IHC |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O95429 |
| Gene ID | 9530 |
| OMIM | 603884 |
| Alias | BAG-4,SODD,Bcl-2-associated athanogene 4,Silencer of death domains,BAG family molecular chaperone regulator 4 |
| Background | Antibody anti-BAG4 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
BAG cochaperone 4 (BAG4), also known as Rem, is a cochaperone that interacts with the HSP70 and HSP90 chaperone proteins to regulate protein folding, degradation, and cellular stress responses BAG4 plays a critical role in managing protein stability and protecting cells from misfolded proteins that can accumulate under stress It is involved in apoptosis regulation, where it interacts with pro-survival signaling pathways to influence cell fate during stress conditions BAG4 also has a significant role in immune cell function and inflammation, where it regulates the degradation of inflammatory signaling molecules and supports immune cell survival under stress Dysregulation of BAG4 has been linked to autoimmune diseases and cancers, where it enhances the stability of oncogenic proteins and prevents apoptotic signaling in tumor cells Additionally, BAG4 is involved in tissue repair and regeneration, particularly in the context of muscle and nervous tissue BAG4’s function in cellular homeostasis, immune regulation, and stress response pathways underscores its importance in maintaining normal cellular function and preventing pathological conditions
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