BAG Family Molecular Chaperone Regulator 4 (BAG4) Antibody

Background

BAG cochaperone 4 (BAG4), also known as Rem, is a cochaperone that interacts with the HSP70 and HSP90 chaperone proteins to regulate protein folding, degradation, and cellular stress responses BAG4 plays a critical role in managing protein stability and protecting cells from misfolded proteins that can accumulate under stress It is involved in apoptosis regulation, where it interacts with pro-survival signaling pathways to influence cell fate during stress conditions BAG4 also has a significant role in immune cell function and inflammation, where it regulates the degradation of inflammatory signaling molecules and supports immune cell survival under stress Dysregulation of BAG4 has been linked to autoimmune diseases and cancers, where it enhances the stability of oncogenic proteins and prevents apoptotic signaling in tumor cells Additionally, BAG4 is involved in tissue repair and regeneration, particularly in the context of muscle and nervous tissue BAG4’s function in cellular homeostasis, immune regulation, and stress response pathways underscores its importance in maintaining normal cellular function and preventing pathological conditions