Mouse ATP Binding Cassette Transporter C6 (ABCC6) Protein

Este producto es parte de ABCC - ATP binding cassette subfamily C
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221€ (10 µg)

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935106861
info@markelab.com
name
Mouse ATP Binding Cassette Transporter C6 (ABCC6) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx650375
tested applications
WB, SDS-PAGE

Description

Mouse ABCC6 Protein is a recombinant Mouse protein produced in a Prokaryotic expression system (E. coli).

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Proteins and Peptides
Immunogen Target
ATP Binding Cassette Transporter C6 (ABCC6)
Host
E. coli
Origin
Mouse
Conjugation
Unconjugated
Observed MW
Molecular Weight: Calculated MW: 29.8 kDa
Concentration: Prior to lyophilization: 200 µg/ml
Sequence Fragment: Ile1260-Ala1498
Tag: N-terminal His tag
Expression
Recombinant
Purity
> 95%
Size 1
10 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
500 µg
Form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-7 working days.
Storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q9R1S7
Alias
ABC34,ARA,EST349056,GACI2,MLP1,MOAT-E,Multidrug resistance-associated protein 6
Background
Protein ABCC6
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

ATP Binding Cassette Subfamily C Member 6 (ABCC6) is primarily recognized for its involvement in regulating tissue calcification processes. Mutations in the ABCC6 gene are linked to pseudoxanthoma elasticum (PXE), a rare genetic disorder characterized by progressive mineralization of elastic fibers in the skin, eyes, and cardiovascular system. ABCC6 functions as an efflux transporter for ATP metabolites, such as inorganic pyrophosphate (PPi), a critical inhibitor of pathological calcification. Expressed predominantly in the liver and kidneys, ABCC6 indirectly regulates extracellular matrix homeostasis and mineralization processes in peripheral tissues. The transporter’s activity impacts not only PXE pathology but also vascular calcification seen in chronic kidney disease and atherosclerosis. ABCC6 remains a focal point of research for developing targeted therapies to modulate its function and mitigate disease progression, emphasizing its importance in both genetic and acquired calcification disorders.

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