Mouse Arachidonate-12-Lipoxygenase, 12R Type (ALOX12B) Protein

Este producto es parte de ALOX - Arachidonate lipoxygenase
Mouse Arachidonate-12-Lipoxygenase, 12R Type (ALOX12B) Protein

Pida mas información

935106861

info@markelab.com

Precio

208€ (10 µg)

Protein ALOX12B

proveedor

Abbexa

reference

abx650288

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Mouse ALOX12B Protein is a recombinant Mouse protein produced in a Prokaryotic expression system (E. coli).


Background

ALOX12B is a lipoxygenase enzyme that specifically oxygenates arachidonic acid to form 12(R)-hydroperoxyeicosatetraenoic acid [12(R)-HPETE], which is further metabolized to 12(R)-HETE. ALOX12B is primarily expressed in the epidermis, where it plays a critical role in skin barrier formation and maintenance. It is involved in the biosynthesis of specialized lipids required for the development of the cornified lipid envelope, a structure essential for skin permeability and protection. Mutations in ALOX12B are linked to autosomal recessive congenital ichthyosis (ARCI), a skin disorder characterized by scaling, dryness, and impaired barrier function due to defective lipid metabolism. Beyond its role in skin biology, ALOX12B has been implicated in inflammation and wound healing processes. Dysregulation of ALOX12B may contribute to skin-related disorders and inflammatory skin diseases, making it an important target for understanding epidermal homeostasis and barrier repair therapies.

Características del producto

category

Proteins and Peptides


origin

Mouse


host

E. coli


immunogen target

Arachidonate-12-Lipoxygenase, 12R Type (ALOX12B)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 39.7 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Glu389-Ile701 Tag: N-terminal His tag


expression

Recombinant


purity

> 90%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

ALOX12B


dry ice

No


availability

Shipped within 5-7 working days.


alias

12R-LOX,12R-lipoxygenase,Epidermis-type lipoxygenase 12,arachidonate lipoxygenase 3


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


Quizá le pueda interesar

Arachidonate-12-Lipoxygenase, 12R Type (ALOX12B) Antibody

Arachidonate-12-Lipoxygenase, 12R Type (ALOX12B) Antibody

proveedor

Abbexa

reference

abx131272

Tested Applications

WB

reactivity

Mouse

status

RUO

clonality

Polyclonal

ALOX12B Antibody is a Rabbit Polyclonal against ALOX12B.

286€ (100 µl)

Ver más

Arachidonate-12-Lipoxygenase, 12R Type (ALOX12B) Antibody

Arachidonate-12-Lipoxygenase, 12R Type (ALOX12B) Antibody

proveedor

Abbexa

reference

abx131273

Tested Applications

WB, IHC, IF/ICC

reactivity

Human

status

RUO

clonality

Polyclonal

ALOX12B Antibody is a Rabbit Polyclonal against ALOX12B.

286€ (100 µl)

Ver más

Arachidonate 12-lipoxygenase, 12R-type (ALOX12B) Antibody

Arachidonate 12-lipoxygenase, 12R-type (ALOX12B) Antibody

proveedor

Abbexa

reference

abx341229

Tested Applications

ELISA, IHC

reactivity

Human

status

RUO

clonality

Polyclonal

Arachidonate 12-lipoxygenase, 12R-type (ALOX12B) Antibody is a Rabbit Polyclonal antibody for the detection of Human ALO...

169€ (20 µl)

Ver más