Arachidonate 12-lipoxygenase, 12R-type (ALOX12B) Antibody

Este producto es parte de ALOX - Arachidonate lipoxygenase
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169€ (20 µl)

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935106861
info@markelab.com
name
Arachidonate 12-lipoxygenase, 12R-type (ALOX12B) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx341229
tested applications
ELISA, IHC

Description

Arachidonate 12-lipoxygenase, 12R-type (ALOX12B) Antibody is a Rabbit Polyclonal antibody for the detection of Human ALOX12B.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Arachidonate 12-lipoxygenase, 12R-type (ALOX12B)
Host
Rabbit
Reactivity
Human
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purity
> 95%
Purification
Purified by Protein G chromatography.
Size 1
20 µl
Size 2
50 µl
Size 3
100 µl
Size 4
200 µl
Size 5
1 ml
Form
Liquid
Tested Applications
ELISA, IHC
Buffer
0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% glycerol.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
O75342
Alias
12R-LOX,12R-lipoxygenase,Epidermis-type lipoxygenase 12,arachidonate lipoxygenase 3
Background
Antibody anti-ALOX12B
Status
RUO

Descripción

ALOX12B is a lipoxygenase enzyme that specifically oxygenates arachidonic acid to form 12(R)-hydroperoxyeicosatetraenoic acid [12(R)-HPETE], which is further metabolized to 12(R)-HETE. ALOX12B is primarily expressed in the epidermis, where it plays a critical role in skin barrier formation and maintenance. It is involved in the biosynthesis of specialized lipids required for the development of the cornified lipid envelope, a structure essential for skin permeability and protection. Mutations in ALOX12B are linked to autosomal recessive congenital ichthyosis (ARCI), a skin disorder characterized by scaling, dryness, and impaired barrier function due to defective lipid metabolism. Beyond its role in skin biology, ALOX12B has been implicated in inflammation and wound healing processes. Dysregulation of ALOX12B may contribute to skin-related disorders and inflammatory skin diseases, making it an important target for understanding epidermal homeostasis and barrier repair therapies.

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