Mouse Apolipoprotein C2 (APOC2) Protein

Este producto es parte de APOC2 - Apolipoprotein C2
Mouse Apolipoprotein C2 (APOC2) Protein

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935106861

info@markelab.com

Precio

221€ (10 µg)

Protein APOC2

proveedor

Abbexa

reference

abx065420

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Recombinant Apolipoprotein C2 (APOC2) is a recombinant Mouse protein produced in a Prokaryotic expression system (E. coli).


Background

APOC2 is a key component of VLDL and chylomicrons, playing an essential role in triglyceride metabolism as an activator of lipoprotein lipase (LPL). APOC2 is primarily synthesized in the liver and secreted into the plasma, where it facilitates the hydrolysis of triglycerides in chylomicrons and VLDL into free fatty acids and glycerol for energy production or storage. A deficiency or mutation in the APOC2 gene leads to familial chylomicronemia syndrome (FCS), a rare genetic disorder characterized by elevated triglyceride levels, severe hyperlipidemia, and recurrent pancreatitis. APOC2 levels are tightly regulated to maintain lipid balance, as excess or reduced APOC2 activity can disrupt triglyceride clearance and promote atherosclerosis. APOC2 functions cooperatively with other apolipoproteins, such as APOA5 and APOE, to regulate lipid metabolism. Therapeutic strategies targeting APOC2 pathways are being explored to improve triglyceride clearance and reduce cardiovascular risk in individuals with dyslipidemia.

Características del producto

category

Proteins and Peptides


origin

Mouse


host

E. coli


immunogen target

Apolipoprotein C2 (APOC2)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 39.4 kDa Observed MW (SDS-PAGE): 39 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ile13-Glu97 Tag: N-terminal His tag and GST tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

APOC2


dry ice

No


availability

Shipped within 5-7 working days.


alias

APOC2, APO-CII, APOC-II, apolipoprotein C2,Apolipoprotein C-II


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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