Mouse Angiopoietin-Related Protein 8 (ANGPTL8) Protein

234€ (10 µg)
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935106861
info@markelab.com
name
Mouse Angiopoietin-Related Protein 8 (ANGPTL8) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx165988
tested applications
WB, SDS-PAGE
Description
Mouse Angiopoietin-Related Protein 8 is a recombinant Mouse protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
Category | Proteins and Peptides |
Immunogen Target | Angiopoietin-Related Protein 8 (ANGPTL8) |
Host | E. coli |
Origin | Mouse |
Conjugation | Unconjugated |
Observed MW | Molecular Weight: Calculated MW: 24.2 kDa Observed MW (SDS-PAGE): 24 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Val16-Ala198 Tag: N-terminal His tag |
Expression | Recombinant |
Purity | > 90% |
Size 1 | 10 µg |
Size 2 | 50 µg |
Size 3 | 100 µg |
Size 4 | 200 µg |
Size 5 | 500 µg |
Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
Tested Applications | WB, SDS-PAGE |
Buffer | Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300. |
Availability | Shipped within 5-7 working days. |
Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
Dry Ice | No |
UniProt ID | Q8R1L8 |
Gene ID | 624219 |
Alias | PRO1185,PVPA599,RIFL |
Background | Protein ANGPTL8 |
Status | RUO |
Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
ANGPTL8, also known as betatrophin, is a hepatokine and adipokine involved in lipid metabolism, glucose homeostasis, and energy regulation. ANGPTL8 functions as a regulator of lipoprotein lipase (LPL) activity, working in coordination with ANGPTL3 to inhibit triglyceride hydrolysis and regulate circulating triglyceride levels. It is primarily expressed in the liver and adipose tissue, where its expression is upregulated in response to feeding and insulin signaling, linking it to nutrient status and energy balance. ANGPTL8 has also been implicated in beta-cell proliferation in the pancreas, where it was initially identified for its potential role in promoting insulin secretion and enhancing pancreatic beta-cell expansion. Dysregulation of ANGPTL8 is associated with obesity, metabolic syndrome, and type 2 diabetes, where altered lipid and glucose metabolism contribute to disease progression. ANGPTL8’s role as a modulator of lipid metabolism and glucose homeostasis makes it a promising target for the treatment of metabolic disorders, including hypertriglyceridemia and insulin resistance.
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