Human Angiopoietin-Related Protein 8 (ANGPTL8) Protein

Pida mas información
935106861
info@markelab.com
Precio
234€ (10 µg)
Protein ANGPTL8
proveedor
Abbexareference
abx065343Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Human ANGPTL8 is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Background
ANGPTL8, also known as betatrophin, is a hepatokine and adipokine involved in lipid metabolism, glucose homeostasis, and energy regulation. ANGPTL8 functions as a regulator of lipoprotein lipase (LPL) activity, working in coordination with ANGPTL3 to inhibit triglyceride hydrolysis and regulate circulating triglyceride levels. It is primarily expressed in the liver and adipose tissue, where its expression is upregulated in response to feeding and insulin signaling, linking it to nutrient status and energy balance. ANGPTL8 has also been implicated in beta-cell proliferation in the pancreas, where it was initially identified for its potential role in promoting insulin secretion and enhancing pancreatic beta-cell expansion. Dysregulation of ANGPTL8 is associated with obesity, metabolic syndrome, and type 2 diabetes, where altered lipid and glucose metabolism contribute to disease progression. ANGPTL8’s role as a modulator of lipid metabolism and glucose homeostasis makes it a promising target for the treatment of metabolic disorders, including hypertriglyceridemia and insulin resistance.
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
Angiopoietin-Related Protein 8 (ANGPTL8)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 23.4 kDa Observed MW (SDS-PAGE): 25 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Met24-Leu196 Tag: N-terminal His tag
expression
Recombinant
purity
> 90%
buffer
Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 0.01% Sarcosyl, 5% Trehalose.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
ANGPTL8
dry ice
No
availability
Shipped within 5-7 working days.
alias
PRO1185,PVPA599,RIFL
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
Quizá le pueda interesar
anti- ANGPTL8 Antibody

proveedor
FineTestreference
FNab09883Tested Applications
ELISA, WB, IHCreactivity
human,mousestatus
RUOclonality
polyclonalPrecio a consultar
Ver másHuman Angiopoietin-Related Protein 8 (ANGPTL8) Protein

proveedor
Abbexareference
abx065343Tested Applications
WB, SDS-PAGEstatus
RUOHuman ANGPTL8 is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
234€ (10 µg)
Ver másAngiopoietin-Related Protein 8 (ANGPTL8) Antibody

proveedor
Abbexareference
abx103102Tested Applications
WB, IHC, IF/ICCreactivity
Humanstatus
RUOclonality
PolyclonalPolyclonal Antibody to Angiopoietin-Related Protein 8 (ANGPTL8).
299€ (100 µl)
Ver más