Mouse Angiopoietin-Related Protein 2 (ANGPTL2) Protein

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935106861
info@markelab.com
Precio
234€ (10 µg)
Protein ANGPTL2
proveedor
Abbexareference
abx065332Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Recombinant ANGPTL2 is a recombinant Mouse protein produced in a Prokaryotic expression system (E. coli).
Background
ANGPTL2 is a secreted glycoprotein that belongs to the angiopoietin-like (ANGPTL) protein family and plays critical roles in inflammation, angiogenesis, and tissue remodeling. ANGPTL2 promotes endothelial cell activation, migration, and vascular permeability, facilitating angiogenesis during wound healing and tissue repair. However, persistent overexpression of ANGPTL2 leads to chronic inflammation and tissue damage, contributing to the development of metabolic disorders, such as obesity and insulin resistance, as well as cardiovascular diseases. ANGPTL2 also enhances cancer progression by promoting tumor angiogenesis, metastasis, and epithelial-mesenchymal transition (EMT). Elevated ANGPTL2 levels are observed in various cancers, including breast, lung, and colorectal cancers, where its activity correlates with poor prognosis. It serves as a biomarker for inflammatory and tumor-associated conditions, linking inflammation to disease pathology. ANGPTL2’s dual role in tissue regeneration and chronic inflammation highlights its significance as a potential therapeutic target in cancer, cardiovascular diseases, and inflammatory disorders.
Características del producto
category
Proteins and Peptides
origin
Mouse
host
E. coli
immunogen target
Angiopoietin-Related Protein 2 (ANGPTL2)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 30.5 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ser267-His493 Tag: N-terminal His tag
expression
Recombinant
purity
> 90%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
ANGPTL2
dry ice
No
availability
Shipped within 5-7 working days.
alias
ARP2,HARP
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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