Mouse Anaphase-promoting complex subunit 4 (ANAPC4) ELISA Kit
Pida mas información
935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for ANAPC4
proveedor
Abbexareference
abx502121Tested Applications
ELISAreactivity
Mousestatus
RUOclonality
Descripción
Mouse Anaphase-promoting complex subunit 4 (ANAPC4) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Anaphase-promoting complex subunit 4 concentrations in serum, plasma, tissue homogenates, cell culture supernatants and other biological fluids.
Background
ANAPC4 is a key structural subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), a multi-subunit E3 ubiquitin ligase that controls the progression of the cell cycle by targeting regulatory proteins for proteasomal degradation. ANAPC4 interacts with other core components, including ANAPC1 and ANAPC5, to form the scaffold that supports APC/C assembly and its enzymatic function. ANAPC4 plays an essential role in facilitating the ubiquitination of substrates such as cyclin B and securin, ensuring their degradation for the metaphase-to-anaphase transition and mitotic exit. Its proper function is necessary for maintaining chromosomal stability and preventing aneuploidy. Dysregulation of ANAPC4 leads to impaired APC/C activity, causing mitotic defects and genomic instability, which are strongly associated with tumorigenesis. ANAPC4 is emerging as a critical factor for cell division and a potential target for therapeutic intervention in proliferative diseases such as cancer.
Características del producto
category
ELISA Kits
immunogen target
Anaphase-promoting complex subunit 4 (ANAPC4)
reactivity
Mouse
test range
0.156 ng/ml - 10 ng/ml
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Serum, plasma, tissue homogenates, cell culture supernatants and other biological fluids.
size 1
96 tests
alias
ANAPC4,APC4,Cyclosome subunit 4
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
ANAPC4
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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