Mouse AMP deaminase 2 (AMPD2) ELISA Kit
Pida mas información
935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for AMPD2
proveedor
Abbexareference
abx501655Tested Applications
ELISAreactivity
Mousestatus
RUOclonality
Descripción
Mouse AMP deaminase 2 (AMPD2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse AMP deaminase 2 concentrations in serum, plasma, tissue homogenates, cell culture supernatants and other biological fluids.
Background
AMPD2 is an isoform of AMP deaminase predominantly expressed in the liver and brain, where it catalyzes the conversion of AMP to IMP as part of the purine nucleotide cycle. AMPD2 plays an essential role in hepatic energy metabolism, facilitating nucleotide turnover and maintaining purine homeostasis during conditions of energy stress. In the liver, AMPD2 activity is tightly linked to gluconeogenesis and urea cycle regulation, as it supplies intermediates such as fumarate for energy generation and ammonia detoxification. Mutations in AMPD2 are associated with pontocerebellar hypoplasia type 9 (PCH9), a severe neurodevelopmental disorder characterized by brain atrophy, microcephaly, and motor impairments due to disrupted purine metabolism. AMPD2 dysfunction leads to impaired nucleotide cycling, energy imbalance, and neuronal loss, highlighting its importance in brain development and function. Its role in liver metabolism and neurological health underscores its potential as a target for metabolic and neurodegenerative disorders.
Características del producto
category
ELISA Kits
immunogen target
AMP deaminase 2 (AMPD2)
reactivity
Mouse
test range
0.156 ng/ml - 10 ng/ml
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Serum, plasma, tissue homogenates, cell culture supernatants and other biological fluids.
size 1
96 tests
alias
AMP deaminase isoform L
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
AMPD2
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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