AMPD2 antibody
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935106861
info@markelab.com
name
AMPD2 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab00371
tested applications
ELISA, WB
Description
AMP deaminase plays a critical role in energy metabolism. Catalyzes the deamination of AMP to IMP and plays an important role in the purine nucleotide cycle.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | adenosine monophosphate deaminase 2(isoform L) (AMPD2) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:5000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 101 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q01433 |
| Gene ID | 271 |
| Alias | AMP deaminase isoform L |
| Background | Antibody anti-AMPD2 |
| Status | RUO |
| Note | Mol. Weight 101 kDa |
Descripción
AMPD2 is an isoform of AMP deaminase predominantly expressed in the liver and brain, where it catalyzes the conversion of AMP to IMP as part of the purine nucleotide cycle. AMPD2 plays an essential role in hepatic energy metabolism, facilitating nucleotide turnover and maintaining purine homeostasis during conditions of energy stress. In the liver, AMPD2 activity is tightly linked to gluconeogenesis and urea cycle regulation, as it supplies intermediates such as fumarate for energy generation and ammonia detoxification. Mutations in AMPD2 are associated with pontocerebellar hypoplasia type 9 (PCH9), a severe neurodevelopmental disorder characterized by brain atrophy, microcephaly, and motor impairments due to disrupted purine metabolism. AMPD2 dysfunction leads to impaired nucleotide cycling, energy imbalance, and neuronal loss, highlighting its importance in brain development and function. Its role in liver metabolism and neurological health underscores its potential as a target for metabolic and neurodegenerative disorders.
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