Mouse Alkaline Phosphatase, Tissue-Nonspecific Isozyme (ALPL) Protein

Este producto es parte de ALPL - Alkaline phosphatase tissue-nonspecific isozyme
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312€ (20 µg)

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935106861
info@markelab.com
name
Mouse Alkaline Phosphatase, Tissue-Nonspecific Isozyme (ALPL) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx694255
tested applications
SDS-PAGE

Description

Mouse Alkaline Phosphatase, Tissue-Nonspecific Isozyme (ALPL) Protein is a recombinant Mouse protein expressed in HEK293 cells.

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Proteins and Peptides
Host
HEK293 cells
Origin
Mouse
Observed MW
Molecular Weight: Calculated MW: 52 kDa  Observed MW (SDS-PAGE): 70 kDa
Sequence Fragment: Met1-Ser502
Tag: C-terminal His tag
Expression
Recombinant
Purity
>80% (SDS-PAGE)
Size 1
20 µg
Size 2
100 µg
Form
Lyophilized Reconstitute in sterile H2O. Do not vortex.
Tested Applications
SDS-PAGE
Buffer
Prior to lyophilization: PBS, pH 7.4, containing 5% - 8% Trehalose, Mannitol and 0.01% Tween-80.
Availability
Shipped within 5-15 working days.
Storage
Store lyophilized between -20 °C and -80 °C.
Dry Ice
No
UniProt ID
P09242
Alias
AP-TNAP,TNS-ALP
Background
Protein ALPL
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

Alkaline phosphatase, tissue-nonspecific isozyme (ALPL) is an enzyme encoded by the ALPL gene in humans. It is also commonly known as tissue-nonspecific alkaline phosphatase (TNAP). ALPL is a type of alkaline phosphatase found in bone, liver, kidney, and intestine. ALPL plays a crucial role in bone mineralization and is involved in the regulation of phosphate metabolism. It catalyzes the hydrolysis of phosphate esters in an alkaline environment, leading to the release of inorganic phosphate. In bone tissue, ALPL is primarily expressed by osteoblasts, where it helps in the mineralization process by generating inorganic phosphate ions, which are essential for the formation of hydroxyapatite crystals, the main component of bone mineral. Deficiencies or mutations in the ALPL gene can lead to a rare genetic disorder known as hypophosphatasia (HPP). HPP is characterized by defective bone mineralization, resulting in weak and soft bones, skeletal abnormalities, and a range of other symptoms depending on the severity of the condition.

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