Mouse ALK Tyrosine Kinase Receptor (ALK) ELISA Kit
Pida mas información
935106861
info@markelab.com
Precio
687.5€ (96 tests)
Elisa Kits ALK
proveedor
Abbexareference
abx515274Tested Applications
ELISAreactivity
Mousestatus
RUOclonality
Descripción
Mouse ALK Tyrosine Kinase Receptor (ALK) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse ALK Tyrosine Kinase Receptor (ALK) concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
The ALK (anaplastic lymphoma kinase) gene encodes a receptor tyrosine kinase, which is a type of cell surface receptor that plays a role in signaling pathways involved in cell growth, proliferation, and differentiation. The ALK protein belongs to the insulin receptor superfamily and is normally expressed in specific tissues during embryonic development, where it helps regulate normal cell growth and development. While ALK expression is typically limited to certain tissues during development, aberrant activation of the ALK gene can occur in various cancers due to chromosomal rearrangements, gene amplification, or activating mutations. These alterations lead to the overexpression or constitutive activation of the ALK protein, contributing to oncogenesis (the formation of cancer).The most well-known oncogenic alteration involving the ALK gene is the fusion of the ALK gene with another gene, resulting in a chimeric fusion protein with constitutive kinase activity. This fusion protein can drive cellular transformation and tumorigenesis.
Características del producto
category
ELISA Kits
immunogen target
ALK Tyrosine Kinase Receptor (ALK)
reactivity
Mouse
test range
0.156 ng/ml - 10 ng/ml
sensitivity
< 0.08 ng/ml
assay type
Sandwich
assay data
Quantitative
detection method
Colorimetric
sample type
Tissue homogenates,Cell lysates,Other biological fluids
size 1
96 tests
alias
CD246
storage
Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit
or code
ALK
dry ice
No
uniprot id
note
This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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