Mouse Alcohol Dehydrogenase 7 (ADH7) Protein
208€ (10 µg)
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935106861
info@markelab.com
name
Mouse Alcohol Dehydrogenase 7 (ADH7) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx652444
tested applications
WB, SDS-PAGE
Description
Mouse Alcohol Dehydrogenase 7 (ADH7) Protein is a Recombinant Mouse protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Alcohol Dehydrogenase 7 (ADH7) |
| Host | E. coli |
| Origin | Mouse |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 56.7 kDa Observed MW: 57 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Gly126-Phe374 Tag: N-terminal His and GST tags |
| Expression | Recombinant |
| Purity | > 90% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | ADH4,Gastric alcohol dehydrogenase, Retinol dehydrogenase |
| Background | Protein ADH7 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
ADH7, also known as retinol dehydrogenase 3, is a member of the class IV alcohol dehydrogenase family and is predominantly expressed in the stomach, esophagus, and liver. Unlike other ADH enzymes, ADH7 shows higher activity towards retinol and long-chain alcohols, playing a critical role in retinoic acid biosynthesis, which is essential for cellular differentiation and growth. Its ability to oxidize ethanol is comparatively limited, but it has significant involvement in detoxifying aromatic and aliphatic alcohols, including those derived from dietary sources. ADH7 is highly relevant in protecting mucosal tissues from alcohol-induced damage, particularly in the upper gastrointestinal tract. Genetic polymorphisms affecting ADH7 activity have been linked to variations in susceptibility to alcohol-related cancers, such as esophageal squamous cell carcinoma, due to differences in acetaldehyde accumulation and oxidative stress. Its role in retinoid metabolism also underscores its significance in regulating developmental and immune processes.
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