Mouse ADAM Metallopeptidase With Thrombospondin Type 1 Motif 4 (ADAMTS4) ELISA Kit

Product specifications

ELISA Kits

ADAM Metallopeptidase With Thrombospondin Type 1 Motif 4 (ADAMTS4)

Mouse

Colorimetric

Quantitative

Sandwich

0.625 ng/ml - 40 ng/ml

< 0.34 ng/ml

Optimal dilutions/concentrations should be determined by the end user.

96 tests

Lyophilized

ELISA

Serum, plasma, tissue homogenates and other biological fluids.

Shipped within 5-12 working days. The validity for this kit is 6 months.

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.

No

Q8BNJ2

KIAA0688, Type 1 Motif 4,A Disintegrin And Metalloproteinase With Thrombospondin Motifs 4 ,Aggrecanase-1,ADAM-TS4,ADAMTS-4

Elisa kits for ADAMTS4

RUO

Validity: The validity for this kit is 6 months.
This product is for research use only.   The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.   Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

ADAMTS4, also known as A Disintegrin And Metalloproteinase with Thrombospondin Motifs 4, is a member of the ADAMTS protein family. ADAMTS4 contains multiple domains, including a metalloproteinase domain responsible for its enzymatic activity, as well as thrombospondin type-1 (TSP-1) motifs. ADAMTS4 is primarily known for its role in extracellular matrix remodeling, particularly in the breakdown of aggrecan, a large proteoglycan found in cartilage. ADAMTS4 cleaves aggrecan at specific sites, leading to the degradation of cartilage matrix and contributing to the pathogenesis of osteoarthritis and other joint-related disorders. It is one of the key enzymes involved in cartilage degradation in osteoarthritis.ADAMTS4 has been implicated in various diseases, particularly osteoarthritis. Elevated levels of ADAMTS4 expression have been observed in osteoarthritic cartilage, synovial fluid, and serum, suggesting its involvement in the disease process. Inhibition of ADAMTS4 activity has been explored as a potential therapeutic strategy for osteoarthritis to prevent cartilage degradation.Research on ADAMTS4 has implications for understanding the pathogenesis of osteoarthritis and other joint-related disorders. Targeting ADAMTS4 activity or expression may represent a promising therapeutic approach for these conditions. Additionally, further research into the regulation and function of ADAMTS4 may provide insights into its roles in normal physiology and other diseases.

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