Mouse Activin A Receptor Type 2B (ACVR2B) Protein

Este producto es parte de ACVR - Activin A Receptor Type
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221€ (10 µg)

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935106861
info@markelab.com
name
Mouse Activin A Receptor Type 2B (ACVR2B) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx065142
tested applications
WB, SDS-PAGE

Description

Mouse Activin A Receptor Type II B (ACVR2B) is a recombinant Mouse protein expressed in E. coli.

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Proteins and Peptides
Immunogen Target
Activin A Receptor Type 2B (ACVR2B)
Host
E. coli
Assay Type
Activity: Not tested
Sequence Fragment: Leu214-Asn350
Tag: N-terminal His tag
Origin
Mouse
Conjugation
Unconjugated
Observed MW
Calculated MW: 17.1 kDa  Observed MW (SDS-PAGE): 17 kDa
Expression
Recombinant
Purity
> 95%
Size 1
10 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
500 µg
Form
Lyophilized
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-7 working days.
Storage
Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles.
Dry Ice
No
UniProt ID
P27040
Alias
Activin receptor type IIB,ACTR-IIB
Background
Protein ACVR2B
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Concentration: Prior to lyophilization: 200 µg/ml

Descripción

ACVR2B is another type II receptor involved in activin and myostatin signaling pathways. It phosphorylates type I receptors (e.g., ACVR1B) to activate SMAD-dependent signaling cascades. ACVR2B regulates processes like muscle growth, reproductive function, and embryonic development. Inhibition of ACVR2B has been explored as a therapeutic approach for muscle-wasting disorders, such as cachexia and muscular dystrophy. Mutations in ACVR2B can impair ligand-receptor interactions, leading to developmental defects.

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