Mouse Activin A Receptor Type 1B (ACVR1B) Protein

Este producto es parte de ACVR - Activin A Receptor Type
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2288€ (1 mg)

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935106861
info@markelab.com
name
Mouse Activin A Receptor Type 1B (ACVR1B) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx065135
tested applications
WB, SDS-PAGE

Description

Recombinant Activin A Receptor Type I B (ACVR1B) is a recombinant Mouse protein produced in a Prokaryotic expression system (E. coli).

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Proteins and Peptides
Immunogen Target
Activin A Receptor Type 1B (ACVR1B)
Host
E. coli
Origin
Mouse
Conjugation
Unconjugated
Observed MW
Molecular Weight: Calculated MW: 21.7 kDa

Concentration: Prior to lyophilization: 200 µg/ml

Sequence Fragment: Ile207-Val385

Tag: N-terminal His tag
Expression
Recombinant
Purity
> 95%
Size 1
1 mg
Size 2
5 mg
Form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
Availability
Shipped within 1-2 months.
Storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q61271
Alias
ACTR-IB,ALK-4,Serine/threonine-protein kinase receptor R2 (SKR2)
Background
Protein ACVR1B
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

ACVR1B, also known as ALK4, is a type I receptor primarily activated by activins, inhibins, and Nodal ligands. This receptor phosphorylates SMAD2/3 to propagate downstream signaling, which regulates cellular processes such as differentiation, proliferation, and embryonic patterning. ACVR1B is expressed in many tissues, particularly during early development. Mutations in ACVR1B have been associated with tumorigenesis and reproductive disorders due to its role in cell cycle regulation and tissue homeostasis.

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Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2(ACVR2A or ACVR2B). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, type-2 receptors(ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor such as ACVR1B. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor. ACVR1B also phosphorylates TDP2.

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