Mouse Activin A Receptor Type 1B (ACVR1B) ELISA Kit

Este producto es parte de ACVR - Activin A Receptor Type
Product Graph
715€ (96 tests)

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.

935106861
info@markelab.com
name
Mouse Activin A Receptor Type 1B (ACVR1B) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx388501
tested applications
ELISA

Description

Mouse Activin A Receptor Type 1B (ACVR1B) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Activin A Receptor Type 1B (ACVR1B) concentrations in tissue homogenates, cell lysates and other biological fluids.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
ELISA Kits
Immunogen Target
Activin A Receptor Type 1B (ACVR1B)
Reactivity
Mouse
Detection Method
Colorimetric
Assay Data
Quantitative
Assay Type
Sandwich
Test Range
78 pg/ml - 5000 pg/ml
Sensitivity
< 46.9 pg/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Form
Lyophilized
Tested Applications
ELISA
Sample Type
Tissue homogenates, cell lysates and other biological fluids.
Availability
Shipped within 5-12 working days. The validity for this kit is 6 months.
Storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
UniProt ID
Q61271
Gene ID
11479
Alias
ACTR-IB,ALK-4,Serine/threonine-protein kinase receptor R2 (SKR2)
Background
Elisa kits for ACVR1B
Status
RUO
Note
Validity: The validity for this kit is 6 months.

This product is for research use only.   The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.   Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

ACVR1B, also known as ALK4, is a type I receptor primarily activated by activins, inhibins, and Nodal ligands. This receptor phosphorylates SMAD2/3 to propagate downstream signaling, which regulates cellular processes such as differentiation, proliferation, and embryonic patterning. ACVR1B is expressed in many tissues, particularly during early development. Mutations in ACVR1B have been associated with tumorigenesis and reproductive disorders due to its role in cell cycle regulation and tissue homeostasis.

Related Products

FNab00129

ACVR1B antibody

Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2(ACVR2A or ACVR2B). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, type-2 receptors(ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor such as ACVR1B. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor. ACVR1B also phosphorylates TDP2.

Ver Producto
P0493

Recombinant Human ACVR1B

Ver Producto
Pr22910

Recombinant Mouse ACVR1B

Ver Producto